Vascular Health Predictive of Amyloid Deposits
Amyloid deposits were noted in the brains of seniors with obesity, diabetes, and estimated cholesterol.
HealthDay News — Individuals with risk factors for cardiovascular disease and stroke in middle age are more likely to have elevated levels of amyloid, according to a study published in the Journal of the American Medical Association.
Rebecca Gottesman, MD, PhD, an assistant professor of neurology at the Johns Hopkins University School of Medicine in Baltimore, and colleagues examined data from 346 individuals whose cardiovascular health had been tracked since 1987 as part of an ongoing study. The average age of the study participants was 52 at the start of the study. Sixty percent were women, and 43% were black. No participants had dementia at the start. About 2 decades later, they were asked to come back and undergo positron emission tomography scans to check for signs of amyloid deposition.
Imaging revealed larger deposits of amyloid in the brains of seniors who smoked, had hypertension, were obese, had diabetes, or had elevated cholesterol levels when they were middle-aged. Two or more risk factors nearly tripled a person's risk of large amyloid deposits. One risk factor alone increased the likelihood of amyloid deposits by 88%. Obesity in particular stood out as a strong risk factor, on its own doubling a person's risk of elevated amyloid later in life.
"An increasing number of midlife vascular risk factors was significantly associated with elevated amyloid," the authors write. "This association was not significant for late-life risk factors. These findings are consistent with a role of vascular disease in the development of Alzheimer disease."
Gottesman RF, Schneider ALC, Zhou Y, et al. Association between midlife vascular risk factors and estimated brain amyloid deposition. JAMA. 2017;317(14):1443-1450. doi: 10.1001/jama.2017.3090