Dyslipidemia Drug Indications
DYSLIPIDEMIA DRUG INDICATIONS
Generic Brand Form Indications
Slow
coronary
athero-
sclerosis		 Lower
total-C		 Lower
LDL-C		 Increase
HDL-C		 Lower
apo B		 Lower
TG		 Sitosterol/
campe-
sterol		 Reduce
risk of
CVD4
BILE ACID SEQUESTRANTS
cholestyr–
amine resin		 — pwd
✓


 
✓
colesevelam Welchol tabs,
oral susp

✓




colestipol Colestid tabs,
granules
✓ ✓




CHOLESTEROL ABSORPTION INHIBITOR
ezetimibe Zetia tabs
✓ ✓
✓
✓2
FIBRATES
fenofibrate Antara caps
✓ ✓ ✓ ✓ ✓

Fenoglide tabs
✓ ✓ ✓ ✓ ✓

Lipofen caps
✓ ✓ ✓ ✓ ✓

Lofibra tabs, caps
✓ ✓ ✓ ✓ ✓

Tricor tabs
✓ ✓ ✓ ✓ ✓

Triglide tabs
✓ ✓ ✓ ✓ ✓

fenofibric acid Fibricor tabs
✓ ✓ ✓ ✓ ✓

Trilipix del-rel caps
✓ ✓ ✓ ✓ ✓

LIPID-REGULATING AGENT
gemfibrozil Lopid scored tabs ✓1



✓
✓
icosapent ethyl Vascepa caps




✓

omega-3-acid
ethyl esters		 Lovaza caps




✓

MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) INHIBITOR
lomitapide mesylate Juxtapid caps
✓ ✓3
✓


NICOTINIC ACID DERIVATIVES
niacin Niaspan ext-rel tabs ✓ ✓ ✓ ✓ ✓ ✓
✓
PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) INHIBITOR
alirocumab Praluent SC inj

✓



✓
evolocumab Repatha SC inj

✓



✓
Repatha Pushtronex SC inj
✓
✓
STATINS (HMG-CoA REDUCTASE INHIBITORS)
atorvastatin Lipitor tabs
✓ ✓ ✓ ✓ ✓
✓
fluvastatin Lescol caps ✓ ✓ ✓ ✓ ✓ ✓
✓
Lescol XL ext-rel tabs ✓ ✓ ✓ ✓ ✓ ✓
✓
lovastatin — tabs ✓ ✓ ✓ ✓ ✓

✓
Altoprev ext-rel tabs ✓ ✓ ✓ ✓ ✓ ✓
✓
pitavastatin Livalo tabs
✓ ✓ ✓ ✓ ✓

Zypitamag tabs
✓ ✓ ✓ ✓ ✓

pravastatin Pravachol tabs ✓ ✓ ✓ ✓ ✓ ✓
✓
rosuvastatin Crestor tabs ✓ ✓ ✓3 ✓ ✓ ✓
✓
simvastatin Zocor tabs
✓ ✓ ✓ ✓ ✓
✓
STATIN + CALCIUM CHANNEL BLOCKER
atorvastatin +
amlodipine		 Caduet tabs
✓ ✓ ✓ ✓ ✓
✓
STATIN + CHOLESTEROL ABSORPTION INHIBITOR
simvastatin +
ezetimibe		 Vytorin tabs
✓ ✓ ✓ ✓ ✓

Classification of Hyperlipoproteinemias
Fredrickson Type    Elevated Lipoproteins     Lipid Elevations (Major)      Lipid Elevations (Minor)
I (rare) chylomicrons triglycerides total-C elevated or no change
IIa LDL total-C —
IIb LDL, VLDL total-C triglycerides
III (rare) IDL total-C/triglycerides —
IV VLDL triglycerides total-C elevated or no change
V chylomicrons, VLDL triglycerides total-C elevated or no change
NOTES

Key:  apo B = apolipoprotein B;  TG = triglycerides;  total-C = total cholesterol;  LDL-C = low-density lipoproteins;  CVD = cardiovascular disease;  IDL = intermediate-density lipoproteins;  VLDL = very low density lipoproteins;  HDL-C = high-density lipoproteins


1 Reduction in risk of coronary artery disease when first line agent is inadequate

2 To reduce elevated sitosterol and campesterol in homozygous familial sitosterolemia

3 Also to reduce elevated non-HDL-C (total-C minus HDL-C)

4 To reduce risk of: MI, stroke, or coronary revascularization procedures, and morbidity/mortality.


FDA-approved indications marked with a ✓. Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. Listed indications may be adjuncts to other therapies, lifestyle changes and/or concomitant drugs.

(Rev. 6/2019)

This article originally appeared on MPR

Topics:

Cardiovascular Disease