Thromboembolic Complications in COVID-19 Discussed
Prevention, diagnosis, and therapeutic management of thromboembolic complications in COVID-19 are discussed in a report published online April 23 in Radiology.
Pulmonary Vasculature
Sotatercept Receives Breakthrough Therapy Status for Pulmonary Arterial Hypertension
The FDA has granted Breakthrough Therapy designation to sotatercept (Acceleron Pharma) for the treatment of pulmonary arterial hypertension (PAH) (World Health Organization Group 1).
Ambrisentan and Tadalafil Combination Therapy Appropriate for CTD-PAH
Combination therapy is appropriate for patients with typical pulmonary arterial hypertension who are categorized as low and intermediate risk at baseline.
Obesity Found to Increase the Risk for Pulmonary Hypertension
Obesity may be associated with a greater risk for pulmonary hypertension.
Trulicity Approved to Reduce Risk for Major Adverse Cardiovascular Events
Remunity is indicated for continuous subcutaneous delivery of Remodulin to treat pulmonary arterial hypertension in patients ≥22 years of age.
Anticoagulation Improves Outcomes in Idiopathic PAH, but Not CTD-PAH
Systemic anticoagulation was found to improve quality-adjusted life years among patients with idiopathic pulmonary arterial hypertension but not among those with connective tissue disease-associated pulmonary arterial hypertension.
Drug-Device Promising in PH-ILD
Bellerophon Therapeutics announced positive topline results from cohort 2 of an ongoing phase 2/3 iNO-PF study of INOpulse delivery system for the treatment of PH-ILD.
FOCUS May Be Useful for Ruling Out Pulmonary Embolism in Patients Presenting to the ED With Abnormal Vital Signs
In patients with abnormal vital signs presenting to the emergency department who are suspected of having a pulmonary embolism, a negative focused cardiac ultrasound examination may be associated with reduced odds of a pulmonary embolism diagnosis.
NIV and CPAP Similarly Improve LV Dysfunction in Obesity Hypoventilation Syndrome With OSA
Treatment with noninvasive ventilation and continuous positive airway pressure provided similar improvements in pulmonary hypertension and left ventricular diastolic dysfunction in obesity hypoventilation syndrome and concomitant severe obstructive sleep apnea.
Cardiac MRI Metrics Help Stratify Mortality Risk in Pulmonary Arterial Hypertension
In patients with pulmonary arterial hypertension, cardiac magnetic resonance imaging metrics are capable of identifying individuals at a low risk for 1-year mortality.
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