LDL-C Polygenic Risk Score and ASCVD in Monogenic Familial Hypercholesterolemia
Elevated LDL-C polygenic scores associated with higher LDL-C levels and increased risk for ASCVD in patients with monogenic familial hypercholesterolemia.
Dyslipidemia
Genetic Background and the Response to Lipid-Lowering Therapy in Familial Hypercholesterolemia
Associations between pathogenic variant positivity and 4-single nucleotide polymorphism score were established in patients with familial hypercholesterolemia in response to lipid-lowering therapy.
Leveraging Machine Learning to Identify Familial Hypercholesterolemia
The use of machine-learning was found to detect familial hypercholesterolemia with high accuracy.
Causal Association Between HDL-C, TG and Gout Identified
A causal relationship between HDL-C and gout was established.
Examining the Efficacy of LDL-C-Lowering Therapies in Older Adults
Lipid-lowering pharmacotherapy targeting LDL-C was found to be safe and effective in reducing CV and cerebrovascular events, with similar efficacy in older and younger patients.
Blood Lipids and Cardiac Structure and Function
Adverse changes in cardiac structure and function were found to be associated with LDL-C and triglycerides plasma concentrations.
Statin Therapy After Revascularization in Peripheral Arterial Occlusive Disease
Statin therapy initiation after index revascularization in patients with peripheral arterial occlusive disease was associated with significant reductions in mortality and cardiovascular events.
New Tool May Improve Prediction and Discrimination of Suspected Obstructive CAD
A novel tool in which clinical risk factors and coronary artery calcium score are added to standard pre-test probability modeling was found to improve risk prediction in suspected obstructive coronary artery disease.
Update on Lipid-Lowering Therapies for CVD
Atherosclerotic cardiovascular disease represents the top global cause of morbidity and mortality.
Elevated LDL-C Associated With Higher Risk for MI, Atherosclerotic CVD in People Ages 70 to 100 Years
Elevated LDL-C levels in people ages 70 to 100 years were found to be associated with a higher absolute risk for myocardial infarction and atherosclerotic cardiovascular disease.
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