Two Novel Loci Identified With Insulin Sensitivity
The associations at BCL2 and FAM19A2 were independent of known cardiometabolic loci.
Diabetes
Nonfunctional Adrenal Tumors May Increase Diabetes Risk
Risk of incident composite diabetes was significantly higher for patients with nonfunctional adrenal tumors vs those without.
Metabolic Syndrome Severity May Be Tied to Menopausal Transition
African-American women in particular experienced more rapid progression in metabolic syndrome severity during pre- and peri-menopausal periods compared to post-menopausal period.
Impaired Glucose Tolerance, Diabetes Progression Increase Mortality Risk
32.1% of patients died, with an overall death rate of 15.9 per 1000 person years.
Higher BMI Associated With Increased Risk of Diabetes, But Not MI
While increases in BMI from 30 years before baseline were not associated with the later risk of MI or death, they were associated with risk of incident diabetes.
Beta-Cell Function Measures Reproduced With Mixed-Meal Tolerance and Arginine Stimulation Tests
Reproducibility was good for the mixed-meal tolerance test and arginine stimulation tests.
Overall Mortality Similar in DCCT/EDIC Cohorts and General Population
Compared with the general US population, mortality in the DCCT intensive therapy group was nonsignificantly lower while mortality in the conventional therapy group was significantly higher.
Brisk Walking vs Jogging in Controlling Blood Glucose Levels
The 3-pronged approach group had an average 9% improvement in oral glucose tolerance vs 7% improvement in the moderate-intensity exercise-only group.
Diabetes and Prediabetes Rates High in American Teenagers
Approximately a third of teenagers who were diagnosed with diabetes didn’t know they had it and the prevalence appears to have doubled from a previous study.
Acute Coronary Syndrome Prognosis Worse With Diabetes
All-cause mortality was highest for patients with diabetes who had STEMI at 1 year, followed by patients with NSTEMI.
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