Cholesterol Levels Have Been Dropping Since 2013 Guidelines
Implementation of guidelines for lipid management in 2013 correlated with a reduction in mean total cholesterol, triglyceride, and LDL-C levels.
Implementation of guidelines for lipid management in 2013 correlated with a reduction in mean total cholesterol, triglyceride, and LDL-C levels.
In patients with prior myocardial infarction (MI)/ischemic stroke, treatment with alirocumab is associated with a reduction in low-density lipoprotein cholesterol (LDL-C), as well as reductions in lipoprotein(a), apolipoprotein B, and non-high-density lipoprotein cholesterol (non-HDL-C), according to study results published in the Journal of Clinical Lipidology. In addition, efficacy and safety results were similar in patients…
The AHA/ACC published a new clinical practice guideline on managing cholesterol and provided a risk assessment report on primary prevention of ASCVD.
A low-density lipoprotein-cholesterol level >4.9 mmol/L in addition to the Dutch Lipid Clinic Network Criteria score may help identify probable/definite or possible familial hypercholesterolemia.
Not reaching LDL-C thresholds places patients at increased risk for cardiovascular events.
Updated cholesterol guidelines offer more personalized cardiovascular disease risk assessment.
Genetic screening for familial hypercholesterolemia would improve the likelihood of a definitive diagnosis and may help clinicians choose the appropriate therapy for patients.
“We are extremely disappointed with the FDA’s decision. We continue to feel strongly that Waylivra demonstrates a favorable benefit/risk profile in people with FCS,” said Akcea CEO, Paula Soteropoulos.
The dosing recommendation was based on data from a double-blind, placebo-controlled study conducted in 62 patients with HeFH undergoing LDL apheresis.
Nutraceuticals may offer a solution to patients who cannot tolerate statins because of severe muscle pain.