Stroke

Apixaban Is Safest Direct Oral Anticoagulant vs Warfarin

Apixaban Is Safest Direct Oral Anticoagulant vs Warfarin

Apixaban reduced risks of major, intracranial, and gastrointestinal bleeding compared with warfarin.

Transfeminine Persons Have Increased VTE Incidence

Transfeminine Persons Have Increased VTE Incidence

More pronounced differences in venous thromboembolism and ischemic stroke in individuals who initiated hormone treatment during follow-up.

High-Risk <i>APOL1</i> Not Tied to CHD, Stroke in Postmenopausal Black Women

High-Risk APOL1 Not Tied to CHD, Stroke in Postmenopausal Black Women

High-risk APOL1 genotype was linked to HFpEF hospitalization in postmenopausal black women.

Marriage May Protect Against Cardiovascular Disease

Marriage May Protect Against Cardiovascular Disease

An association was seen between marital status and risk and prognosis of coronary heart disease or stroke.

Half of Cardiovascular Events Occur Between 2 to 5 Years After Stroke

Half of Cardiovascular Events Occur Between 2 to 5 Years After Stroke

The rate of a composite of stroke, acute coronary syndrome, or death from cardiovascular causes occurred in 12.9% of patients; 50.1% of events occurring in the second to fifth years.

Ischemic Stroke Risk Increased With Higher Platelet Reactivity Post-DES Implantation

Ischemic Stroke Risk Increased With Higher Platelet Reactivity Post-DES Implantation

High platelet reactivity was associated with an increased risk for ischemic stroke in patients who had undergone drug-eluting stent implantation.

Rivaroxaban Use in Older Patients: Does Age Influence Safety, Efficacy?

Rivaroxaban Use in Older Patients: Does Age Influence Safety, Efficacy?

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Data from large Phase 3 studies showed that treatment with rivaroxaban was found to be safe and effective in older patients.

Patient With COPD, Smoking History Presents to ED With Sensory Loss

Patient With COPD, Smoking History Presents to ED With Sensory Loss

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A 72-year-old man with a 50 pack-year smoking history and multiple comorbidities, including COPD, presents to the emergency department with left-sided hemiparesis and sensory loss.

New Coagulation Monitoring Device Allows for Wireless Reporting of INR Results

New Coagulation Monitoring Device Allows for Wireless Reporting of INR Results

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The system is intended for properly selected trained users ≥22 years of age who have been stabilized on anticoagulation with vitamin K antagonists for ≥6 weeks.

Disparities for Recurrent Hemorrhagic Stroke Risk Unexplained

Disparities for Recurrent Hemorrhagic Stroke Risk Unexplained

Higher risk for second hemorrhagic stroke in blacks and Hispanics is not fully explained by hypertension severity.

Under New Guidelines, More Stroke Survivors With Hypertension Diagnosis

Under New Guidelines, More Stroke Survivors With Hypertension Diagnosis

More stroke survivors are not within the new recommended blood pressure targets compared with Joint National Committee report.

Stroke Risk Highest in Paroxysmal Afib With Greater Burden of Afib

Stroke Risk Highest in Paroxysmal Afib With Greater Burden of Afib

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A greater burden of atrial fibrillation or flutter in patients with paroxysmal atrial fibrillation was associated with a higher risk for stroke when not taking anticoagulants.

No Consistent Cardiovascular Benefit Seen for Supplements

No Consistent Cardiovascular Benefit Seen for Supplements

The evidence for preventive benefits, no effect, or elevated risk for all-cause mortality was generally moderate- or low-quality.

CDC: Outpatient Rehab Rates Suboptimal for Stroke Survivors

CDC: Outpatient Rehab Rates Suboptimal for Stroke Survivors

Based on data from 4 states, in 2015, 35.5% of adult stroke survivors used outpatient rehab.

Extended INR Test Intervals Safe for Warfarin-Treated Patients

Extended INR Test Intervals Safe for Warfarin-Treated Patients

Similar number of out-of-range next INR values were seen in patients with and without extended testing interval.

Clopidogrel Plus Aspirin Cuts Ischemic Events in Stroke, TIA

Clopidogrel Plus Aspirin Cuts Ischemic Events in Stroke, TIA

The combination of clopidogrel and aspirin was associated with a reduced risk for major ischemic events, but also with increased risk for major hemorrhage within 90 days.

Alteplase Good for Ischemic Stroke With Unknown Onset Time

Alteplase Good for Ischemic Stroke With Unknown Onset Time

There were better functional outcomes in ischemic stroke with alteplase, but a small increased rate of intracranial hemorrhage.

FDA Approves Epoetin Alfa Biosimilar Retacrit

FDA Approves Epoetin Alfa Biosimilar Retacrit

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The approval of Retacrit was based on a review of evidence that included human pharmacokinetic/pharmacodynamic data and clinical immunogenicity data which demonstrated a high degree of similarity between Retacrit and its reference product.

Sickle cell trait not linked to increased risk of ischemic stroke

In this meta-analysis of prospective population-based studies, sickle cell trait (SCT) was not associated with any difference in risk for first ischemic stroke.

Folic Acid May Cut Stroke Risk in High-Risk Hypertensive Patients

Folic Acid May Cut Stroke Risk in High-Risk Hypertensive Patients

Patients with hypertension may lower their stroke risk with folic acid supplements.

Frequency of Sauna Bathing Linked to Reduced Stroke Risk

Frequency of Sauna Bathing Linked to Reduced Stroke Risk

Frequent sauna bathing is associated with reduced risk of future stroke in adults.

Physical Therapy Helps Recover Arm Function in Chronic Stroke

Physical Therapy Helps Recover Arm Function in Chronic Stroke

Physical therapy promotes the recovery of arm function and neuroplasticity in all patients with chronic stroke.

Andexxa Approved for Reversing Anticoagulant Activity of Rivaroxaban, Apixaban

Andexxa Approved for Reversing Anticoagulant Activity of Rivaroxaban, Apixaban

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Andexxa, a recombinant modified human Factor Xa (FXa) protein, was approved under the FDA's Accelerated Approval pathway.

Anxiety May Increase Stroke, Intracranial Hemorrhage in Atrial Fibrillation

Anxiety May Increase Stroke, Intracranial Hemorrhage in Atrial Fibrillation

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Anxiety may increase the risk for ischemic stroke and intracranial hemorrhage in patients with atrial fibrillation.

Previous Stroke Tied to Higher Risks in Aortic Valve Replacement

Previous Stroke Tied to Higher Risks in Aortic Valve Replacement

Previous stroke within 3 months of surgical aortic valve replacement is risk factor for recurrent ischemic stroke and MACE.

Clopidogrel Plus Aspirin Reduces Recurrent Stroke Risk in Patients With Multiple Acute Infarctions

Clopidogrel Plus Aspirin Reduces Recurrent Stroke Risk in Patients With Multiple Acute Infarctions

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Investigators assessed the impact of infarction patterns on the safety and effectiveness of dual antiplatelet therapy with clopidogrel and aspirin.

Tenecteplase Appears Superior to Alteplase After Ischemic Stroke

Tenecteplase Appears Superior to Alteplase After Ischemic Stroke

Tenecteplase administered within 4.5 hours after symptoms linked to higher reperfusion and better functional outcomes in ischemic stroke.

High FGF-23 Linked to Recurrent Cardiac Events After ACS

High FGF-23 Linked to Recurrent Cardiac Events After ACS

FGF-23 concentrations in the top quartile were independently linked to greater risk for CV death and heart failure hospitalization.

Praxbind Gains Full FDA Approval as Pradaxa Reversal Agent

Praxbind Gains Full FDA Approval as Pradaxa Reversal Agent

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Complete reversal was seen within 4 hours in the majority of patients, as measured by ecarin clotting time (ECT 82%) or diluted thrombin time (dTT 99%). In addition, there was a low late of thrombotic events and no new safety events were reported.

Rapid Deployment Valve for Aortic Stenosis Ups Stroke Risk

Rapid Deployment Valve for Aortic Stenosis Ups Stroke Risk

Rapid deployment valve use linked to increased rates of pacemaker implantation and disabling stroke, but not mortality.

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