Pulmonary Vascular Disorders

IVC Filters May Increase Mortality Risk in Elderly Patients With PE

IVC Filters May Increase Mortality Risk in Elderly Patients With PE

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The use of inferior vena cava filters may increase the risk for 30-day and 1-year mortality in elderly patients with acute pulmonary embolism.

Treprostinil May Have Antithrombotic Effect in Pediatric Pulmonary Hypertension

Treprostinil May Have Antithrombotic Effect in Pediatric Pulmonary Hypertension

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Treatment with treprostinil has demonstrated potential antithrombotic mechanisms of action in pediatric patients with pulmonary arterial hypertension.

PAH Survival May Increase Risk for Pulmonary Artery Aneurysms

PAH Survival May Increase Risk for Pulmonary Artery Aneurysms

The time course of pulmonary arterial hypertension was an independent risk factor for pulmonary artery aneurysms.

Higher Risk for VTE With Oral vs Transdermal Hormone Replacement Therapy

Higher Risk for VTE With Oral vs Transdermal Hormone Replacement Therapy

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Oral preparations of hormone replacement therapy for the treatment of menopausal symptoms are associated with a greater risk for VTE compared with transdermal formulations.

Prognostic Relevance of Cardiopulmonary Exercise Testing in Low-Risk Pulmonary Arterial Hypertension

Prognostic Relevance of Cardiopulmonary Exercise Testing in Low-Risk Pulmonary Arterial Hypertension

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Combinations of VO2 and change in CI during follow-up visits are valuable prognosis markers in low-risk patients with PAH.

Exercise Capacity in CTEPH Improved With Treprostinil

Exercise Capacity in CTEPH Improved With Treprostinil

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Compared with the low dose, high-dose subcutaneous treprostinil increased 6-minute walk distances in patients with chronic thromboembolic pulmonary hypertension.

PAH: An Under-Recognized Complication of Adult-Onset Still's Disease

PAH: An Under-Recognized Complication of Adult-Onset Still's Disease

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PAH is an under-diagnosed complication of adult-onset Still disease.

Comorbid Mental Disorder Prevalence Higher in Pulmonary Arterial Hypertension

Comorbid Mental Disorder Prevalence Higher in Pulmonary Arterial Hypertension

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People with pulmonary arterial hypertension display higher levels of depression and anxiety than previously estimated by healthcare workers.

Pulmonary Hypertension Screening Adaptations for Adult Congenital Heart Disease

Pulmonary Hypertension Screening Adaptations for Adult Congenital Heart Disease

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Because standardized approaches for echocardiographic screening are impractical for certain subgroups of people with congenital heart disease, experts offered screening adaptations for pulmonary hypertension.

Orenitram Decreased Risk of Morbidity/Mortality Event in PAH Trial

Orenitram Decreased Risk of Morbidity/Mortality Event in PAH Trial

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FREEDOM-EV was an international, multicenter, randomized, double-blind, placebo-controlled trial (N=690) that randomized patients to 3 daily doses of Orenitram or placebo.

Generic Version of Adcirca Now Available for Pulmonary Arterial Hypertension

Generic Version of Adcirca Now Available for Pulmonary Arterial Hypertension

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Tadalafil, a phosphodiesterase 5 (PDE5) inhibitor, is indicated to treat pulmonary arterial hypertension to improve exercise ability.

Pulmonary-Systemic Pulse Pressure Ratio Linked to PH Mortality

Pulmonary-Systemic Pulse Pressure Ratio Linked to PH Mortality

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Patients with group 1 pulmonary hypertension who had a higher pulmonary-systemic pulse pressure ratio had a higher risk for mortality.

Segmental Pulmonary Hypertension: Management of New Classification

Segmental Pulmonary Hypertension: Management of New Classification

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Segmental pulmonary hypertension can result from several conditions, such as complex pulmonary atresia, hemitruncus arteriosus, absence/atresia of a single pulmonary artery, and an anomalous pulmonary artery from the aorta feeding a single lung segment.

Implantable System for Remodulin Approved for Patients With PAH

Implantable System for Remodulin Approved for Patients With PAH

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Remodulin is a prostacyclin vasodilator indicated for the treatment of pulmonary arterial hypertension.

Asthma and Poorly Controlled Asthma May Increase Atrial Fibrillation Risk

Asthma and Poorly Controlled Asthma May Increase Atrial Fibrillation Risk

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Individuals with clinician-diagnosed asthma were at an estimated 38% higher risk for atrial fibrillation.

Newly Diagnosed, Limitation-Free PH at Risk for Exercise Capacity Reductions

Newly Diagnosed, Limitation-Free PH at Risk for Exercise Capacity Reductions

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Patients with World Health Organization Functional Class I pulmonary hypertension experienced a significant reduction in exercise capacity following the shuttle walk test.

Tricuspid Regurgitation Velocity Unreliable Indicator of Pulmonary Hypertension

Tricuspid Regurgitation Velocity Unreliable Indicator of Pulmonary Hypertension

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Pulmonary hypertension was confirmed by invasive methods in 68% and 47% of patients with and without a measurable tricuspid regurgitation velocity, respectively.

Early Pulmonary Vascular Disease Onset Risk in Adults Born Preterm

Early Pulmonary Vascular Disease Onset Risk in Adults Born Preterm

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Increased pulmonary pressures, right ventricular dysfunction, and a stiffer pulmonary vascular bed were typical characteristics of early pulmonary vascular disease onset in young adults who were born preterm.

PAH Mortality Rates Comparable With ERA or PDE5 Inhibitor Therapy

PAH Mortality Rates Comparable With ERA or PDE5 Inhibitor Therapy

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There were no significant differences in pulmonary arterial hypertension survival based on therapy type, age was an important modifier.

Pulmonary Arterial Stiffness Related to mPAP and Heart Rate in Idiopathic PAH

Pulmonary Arterial Stiffness Related to mPAP and Heart Rate in Idiopathic PAH

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Pulmonary arterial stiffness was related to mean pulmonary arterial pressure and heart rate in patients with untreated idiopathic pulmonary arterial hypertension.

Prognostic Model for Mortality in Pediatric Pulmonary Hypertension

Prognostic Model for Mortality in Pediatric Pulmonary Hypertension

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The Pediatric Index Pulmonary Hypertension Intensive Care Mortality model was compared with the Pediatric Risk of Mortality 2 and 3 models to determine the best model for predicting mortality.

RV Trabecular Complexity Fractal Analysis: Measuring Remodeling in PH

RV Trabecular Complexity Fractal Analysis: Measuring Remodeling in PH

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The fractal dimension of right ventricular trabecular complexity was a good reproducible marker of remodeling in pulmonary hypertension.

RV Base/Apex Ratio May Help Diagnose Pulmonary Arterial Hypertension in Children

RV Base/Apex Ratio May Help Diagnose Pulmonary Arterial Hypertension in Children

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Right ventricular base/apex ratio reference values may help clinicians diagnose children with pulmonary arterial hypertension.

Improved Counseling Needed in Pregnant Patients With Pulmonary Arterial Hypertension

Improved Counseling Needed in Pregnant Patients With Pulmonary Arterial Hypertension

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Many healthcare providers reported that they often do not have the time to counsel their patients with pulmonary arterial hypertension on pregnancy risks.

PAH in Congenital Heart Disease: Expert Q&A on Challenges and Advances

PAH in Congenital Heart Disease: Expert Q&A on Challenges and Advances

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Management strategies were discussed for subtypes of PAH-congenital heart disease including Eisenmenger syndrome, PAH with persistent systemic to pulmonary shunts, and PAH with small or coincidental defect or PAH after defect closure.

Improving Risk Stratification, Diagnostic Accuracy in PAH With Cardiopulmonary Exercise Testing

Improving Risk Stratification, Diagnostic Accuracy in PAH With Cardiopulmonary Exercise Testing

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Cardiopulmonary exercise testing can be an important diagnostic and prognostic tool in pulmonary arterial hypertension.

Cyanosis From PH or Congenital Heart Disease Responds Well to IV Ferrous Carboxymaltose

Cyanosis From PH or Congenital Heart Disease Responds Well to IV Ferrous Carboxymaltose

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After iron supplementation, patients with cyanosis experienced significant improvements in hemoglobin concentration, hematocrit, mean corpuscular volume, ferritin, and transferrin saturation

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

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There was no significant difference in efficacy between sildenafil and bosentan initial combination therapy and sildenafil monotherapy in patients with systemic sclerosis-related pulmonary arterial hypertension.

CTEPH Increases Risk for Sleep Disordered Breathing

CTEPH Increases Risk for Sleep Disordered Breathing

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Precapillary pulmonary hypertension and obstructive sleep apnea may be causative factors for central sleep apnea and pulmonary hypertension, respectively.

Arrhythmia Associated With Higher Mortality in Congenital Heart Disease-Related PAH

Arrhythmia Associated With Higher Mortality in Congenital Heart Disease-Related PAH

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Arrhythmia was a significant predictor of mortality in adult patients with congenital heart disease and pulmonary arterial hypertension.

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