Pneumonia Risk Elevated With Proton Pump Inhibitor Use In Dementia
Pneumonia risk was decreased with cholinesterase inhibitors and histamine receptor-2 antagonists.
HealthDay News — For patients with dementia, proton pump inhibitor (PPI) use is associated with increased risk of pneumonia, according to a study published online in the Journal of the American Geriatrics Society.
Sai-Wai Ho, MD, from the Chung Shan Medical University in Taichung, China, and colleagues conducted a retrospective cohort study involving 786 patients with dementia with new PPI usage and 786 matched patients with dementia without PPI usage.
The researchers found that patients with PPI usage had higher incidence of pneumonia (adjusted hazard ratio [aHR]: 1.89). Independent risk factors for pneumonia included age, male gender, underlying cerebrovascular disease, chronic pulmonary disease, congestive heart failure, diabetes, and antipsychotic use (aHR: 1.05, 1.57, 1.30, 1.39, 1.54, 1.54, and 1.29, respectively). Pneumonia risk was decreased with usage of cholinesterase inhibitors and histamine receptor-2 antagonists.
"PPI usage in dementia patients is associated with an 89 percent increased risk of pneumonia," the authors write.
Ho S-W, Teng Y-H, Yang S-F, et al. Association of proton pump inhibitor usage with risk of pneumonia in dementia patients [published online March 21, 2017]. J Am Geriatr Soc. doi:10.111/jgs.14813