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Acute decompensated heart failure in children is characterized by high burdens of comorbidities, mortality, and frequent readmission, especially among patients with underlying congenital heart disease.

Patients with HFrEF who were diabetic or prediabetic had reduced left ventricular volumes following therapy with empagliflozin.

Microvascular disease was found to be associated with lower limb amputation, a risk increased in a synergistic manner in individuals with comorbid PAD.

Individuals living with HIV, particularly those with comorbid kidney disease, were found to be at increased risk for cardiovascular disease.

Pregnant women with congenital heart defects are more likely to have comorbidities and experience adverse events during delivery.

Patients with acute coronary syndrome and diabetes have significantly higher rates of cardiogenic shock and lower rates of revascularization.

Patients with comorbid congestive heart failure who received parenteral nutrition experienced increased negative outcomes in their hospital stay.

Mortality rate trends for newly diagnosed heart failure patients indicate that the overall reduction in mortality across all age groups is being hindered by high and increasing rates of noncardiovascular events.

Despite declining incidence, heart failure hospitalization is increased among individuals with diabetes.

There is a substantial burden, unawareness, and undertreatment of several systemic comorbidities—particularly cardiovascular and psychiatric—in patients with HS.