Metabolic

Heritability of BMI Stronger in Obesogenic Environments

Heritability of BMI Stronger in Obesogenic Environments

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Heritability of BMI was significantly higher in children living in high-risk obesogenic environments compared with those living in low-risk environments.

High Variability in Metabolic Parameters May Predict All-Cause Mortality

High Variability in Metabolic Parameters May Predict All-Cause Mortality

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High variability of fasting blood glucose and total cholesterol levels, systolic blood pressure, and BMI may be an independent predictor of cardiovascular events.

Coenzyme Q10 Supplementation May Reduce Statin-Induced Myopathy

Coenzyme Q10 Supplementation May Reduce Statin-Induced Myopathy

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Supplementation with coenzyme Q10 may be an effective approach for managing statin-induced myopathy.

Significant Mortality Reduction With Empagliflozin in T2D and Established CVD

Significant Mortality Reduction With Empagliflozin in T2D and Established CVD

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For this analysis, the authors used follow-up data from all 7020 patients included in the EMPA-REG OUTCOME trial to estimate the effect of empagliflozin on all-cause mortality vs placebo over the duration of a patient's lifetime.

Lorcaserin Decreases Incident Diabetes Risk in Overweight Patients

Lorcaserin Decreases Incident Diabetes Risk in Overweight Patients

Lorcaserin reduces the risk for diabetes in obese or overweight patients with prediabetes or without diabetes and reduces HbA1c among those with diabetes.

Atopic Dermatitis Likely Not Associated With Cardiometabolic Disease

Atopic Dermatitis Likely Not Associated With Cardiometabolic Disease

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Atopic dermatitis was not found to be an independent risk factor for cardiometabolic disease in this meta-analysis.

Triglyceride-Lowering Alleles Associated With Reduced Coronary Artery Disease Risk

Triglyceride-Lowering Alleles Associated With Reduced Coronary Artery Disease Risk

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Triglyceride-lowering variants in the lipoprotein lipase pathway are independently associated with protection from coronary artery disease and type 2 diabetes.

WHO Issues Recommendations for T2DM Treatment Intensification

WHO Issues Recommendations for T2DM Treatment Intensification

WHO has also made recommendations for type of insulin for type 1 and type 2 diabetes in low-resource settings.

High and Low Carbohydrate Diets Linked to Increased Mortality

High and Low Carbohydrate Diets Linked to Increased Mortality

Increase in mortality when carbohydrates were exchanged for animal-derived fat or protein.

Positive Link for BMI and Blood Pressure in Chinese Population

Positive Link for BMI and Blood Pressure in Chinese Population

The increase in blood pressure ranged from 0.8 to 1.7 mm Hg per unit BMI in patients who were not taking antihypertensive medication.

Lorcaserin Facilitates Weight Loss Without Increasing Risk of Major CV Events

Lorcaserin Facilitates Weight Loss Without Increasing Risk of Major CV Events

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In the CAMELLIA-TIMI 61 study, 12,000 overweight or obese patients with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors were randomized to receive either lorcaserin 10mg twice daily or placebo.

Increased First-Trimester HbA1c Predicts Gestational Diabetes

Increased First-Trimester HbA1c Predicts Gestational Diabetes

First-trimester HbA1c significantly improved gestational diabetes prediction compared with conventional risk factors.

Inflammation and Endothelial Stress Associated With CV Risk in Type 2 Diabetes With Manifest CVD

Inflammation and Endothelial Stress Associated With CV Risk in Type 2 Diabetes With Manifest CVD

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The risk for cardiovascular events in patients with type 2 diabetes without manifest cardiovascular disease is primarily related to the severity of atherosclerosis.

Low Predictive Power of Biomarkers for Estimated Glomerular Filtration Rate Decline

Low Predictive Power of Biomarkers for Estimated Glomerular Filtration Rate Decline

While certain biomarkers are associated with eGFR decline in patients with type 2 diabetes, their predictive power is low.

Death Risk Not Increased in T2DM When Risk Factors Within Target

Death Risk Not Increased in T2DM When Risk Factors Within Target

Little or no excess risk of death, MI, or stroke in patients with type 2 diabetes who had their 5 risk factor variables within target ranges.

Weight Gain After Quitting Smoking May Increase T2DM Risk

Weight Gain After Quitting Smoking May Increase T2DM Risk

However, the temporary increase in type 2 diabetes risk does not attenuate benefits on total and CVD mortality.

Casual Glucose Concentrations Predict Post-Surgical Myocardial Injury

Casual Glucose Concentrations Predict Post-Surgical Myocardial Injury

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Glucose concentration assessment before noncardiac surgery may help clinicians predict the risk for postoperative myocardial injury in patients with and without diabetes.

High BMI May Hurt Cardiovascular Health in Teens, Young Adults

High BMI May Hurt Cardiovascular Health in Teens, Young Adults

Using a combination of methodologies suggests higher BMI may increase blood pressure and left ventricular mass index in youth.

Bariatric Surgery Lowers Microvascular Disease Risk

Bariatric Surgery Lowers Microvascular Disease Risk

Bariatric surgery was associated with significantly lower risk for incident microvascular disease at 5 years.

Better Cardiac Profiles With Exercise, Less Sitting in Early Old Age

Better Cardiac Profiles With Exercise, Less Sitting in Early Old Age

Greater light and moderate-to-vigorous intensity physical activity were tied to a more favorable cardiac profile in adults aged 60 to 64.

Healthy Lifestyle With Diabetes Reduces Cardiovascular Risk

Healthy Lifestyle With Diabetes Reduces Cardiovascular Risk

The benefit of adopting a healthy lifestyle was seen even after the type 2 diabetes diagnosis was made.

American Heart Association Urges Screen Time Limits for Youth

American Heart Association Urges Screen Time Limits for Youth

Increasing screen time trends may have a negative cardiometabolic effect on young children.

Elevated HDL-C May Not Benefit Postmenopausal Women

Elevated HDL-C May Not Benefit Postmenopausal Women

Higher HDL cholesterol in postmenopausal women may mask heart disease risk.

CDC: Half of US Adults Tried to Lose Weight From 2013 to 2016

CDC: Half of US Adults Tried to Lose Weight From 2013 to 2016

Exercising and eating less were top weight loss methods, and more women than men attempted weight loss.

Single Threshold May Not Be Feasible for Gestational Diabetes

Single Threshold May Not Be Feasible for Gestational Diabetes

Diagnostic thresholds for gestational diabetes should be adapted using local populations.

Nut Intake Reduces HbA1c Among Adults With T2DM

Nut Intake Reduces HbA1c Among Adults With T2DM

A full-nut dose lowered HbA1c and estimated cholesterol levels in LDL particles of a certain diameter.

Diabetes Diagnosis May Affect Health Behaviors of Family

Diabetes Diagnosis May Affect Health Behaviors of Family

Small changes in health behaviors were seen in partners of those newly diagnosed with diabetes.

Canagliflozin Trial for T2D With CKD Stopped Early Due to Positive Results

Canagliflozin Trial for T2D With CKD Stopped Early Due to Positive Results

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A clinical trial assessing canagliflozin (Invokana; Janssen) as an addition to standard-of-care in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) has been stopped early after meeting its pre-specified efficacy criteria.

Improving Sleep Quality May Reduce Cardiovascular Risk in Bipolar Disorder

Improving Sleep Quality May Reduce Cardiovascular Risk in Bipolar Disorder

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The relationship between circadian rhythm and sleep measures and components of metabolic syndrome in patients with bipolar disorder.

New Data Support Long-Term Cardiovascular Safety of Linagliptin in T2D

New Data Support Long-Term Cardiovascular Safety of Linagliptin in T2D

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Results showed the overall safety profile of linagliptin in study patients, including adults with kidney disease, was consistent with previous data.

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