Type 2 Diabetes Medication Adherence Not Reported in Studies
Researchers found that the mean rate of poor adherence was 37.8%, and only 5 studies provided adjusted estimates.
HealthDay News — Studies often fail to include information on outcomes by medication adherence in type 2 diabetes, according to research published online in Diabetes Care.1
Kamlesh Khunti, MD, PhD, from Leicester General Hospital in the United Kingdom, and colleagues examined the correlation between medication adherence and risk of cardiovascular disease (CVD), all-cause mortality, and hospitalization in type 2 diabetes. Eligible studies were reviewed and data extracted; a random-effects meta-analysis was used to calculate pooled relative risks (RRs). Data were included for 8 observational studies with 318,125 adults.
The researchers found that the mean rate of poor adherence was 37.8%. Five studies only provided adjusted estimates. The RRs of good vs poor adherence to medication were .72 and .90 for all-cause mortality and hospitalization, respectively. There was no evidence of small-study bias. CVD outcomes were reported by adherence in only 1 study.
"Pooled estimates from available observational studies suggest that good medication adherence is associated with reduced risk of all-cause mortality and hospitalization in people with type 2 diabetes, although bias cannot be excluded as an explanation for these findings," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
- Khunti K, Seidu S, Setor K, Davies M. Association between adherence to pharmacotherapy and outcomes in type 2 diabetes: a meta-analysis. Diabetes Care. 2017. doi: 10.2337/dc16-1925. [Epub ahead of print]