Subtle Elevations in Lipids, Glucose Over Time May Increase Diabetes Risk
More than 20 years before T2D diagnosis, individuals had higher levels of fasting glucose and triglycerides.
HealthDay News — Risk of developing type 2 diabetes (T2D) is associated with subtle elevations of glucose and lipids more than 20 years before diagnosis, according to a study published in Diabetes, Obesity and Metabolism.
Håkan Malmström, from the Karolinska Institutet in Stockholm, and colleagues assessed data from 296,428 individuals participating in the Swedish AMORIS cohort. All had a fasting glucose from a health exam during the baseline period (1985 to 1996) and were followed through 2012.
The researchers found that 28,244 new T2D cases were identified over the study period, yielding an average 20-year risk of 8.1%.
Overweight and obese individuals and those with elevated fasting glucose (fGlu) and triglycerides (TG) had a substantially increased risk in both men and women. More than 20 years before diagnosis, T2D cases had higher mean body mass index, fGlu, and TG vs controls. The difference in fGlu between those who developed T2D and controls increased over time.
"This suggests that diabetogenic processes tied to chronic insulin resistance operate for decades prior to the development of T2D," the authors wrote.
Disclosures: Several authors disclosed financial ties to the pharmaceutical industry.
Malmström H, Walldius G, Carlsson S, et al. Elevations of metabolic risk factors 20 years or more before diagnosis of type 2 diabetes- experience from the AMORIS study [published online February 5, 2018]. Diabetes Obes Metab. doi:10.1111/dom.13241