Beta-Cell Glucose Sensitivity Impaired After Gastric Bypass

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Reduced glucose effectiveness was also seen among the gastric bypass subjects
Reduced glucose effectiveness was also seen among the gastric bypass subjects

HealthDay News — Individuals with prior Roux-en-Y gastric bypass (GB) have blunted β-cell sensitivity to changes in glycemia, according to a study published in Diabetes, Obesity and Metabolism.

Marzieh Salehi, MD, from the University of Cincinnati College of Medicine, and colleagues examined β-cell glucose sensitivity in the absence of meal stimulation and insulinotropic gut factors in 12 subjects without diabetes with prior GB surgery and seven matched non-surgical controls with normal glucose tolerance. During a graded glucose infusion, blood glucose and insulin secretion rates were measured. Insulin sensitivity (SI) and glucose effectiveness (SG) were determined.

The researchers found that GB subjects and controls had comparable SI. During the highest dose of glucose infusion, the GB subjects had relative hyperglycemia associated with significantly reduced β-cell glucose sensitivity throughout both step-up (GB: 34 ± 6 vs control: 82 ± 9 pmol.min-1.mM-1.L; P < .0001) and step-down (GB: 31 ± 6 vs control: 74 ± 9 pmol.min-1.mM-1.L; P <.0001) phases of the glucose infusion. Reduced SG was also seen among the GB subjects (GB: 0.04 ± 0.00 vs control: 0.07 ± 0.01 min-1; P = .004).

"In the absence of enteric stimuli β-cell sensitivity to changes in glycemia is blunted among individuals with GB, indicating a significant shift in a fundamental property of β-cell function several years after surgery," the authors write.

Reference

Salehi M, Gastaldelli A, D'Alessio DA. Beta-cell sensitivity to glucose is impaired after gastric bypass surgery [published online November 20, 2017]. Diabetes Obes Metab. doi: 10.1111/dom.13165.

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