TAVR, SAVR Mortality Risk Increased With Depression

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There was a 3-fold increase in mortality at 12 months among participants with persistent depression.
There was a 3-fold increase in mortality at 12 months among participants with persistent depression.

HealthDay News — The presence of depressive symptoms among older adults undergoing transcatheter (TAVR) or surgical (SAVR) aortic valve replacement increases the risk of mortality, according to research published in JAMA Cardiology.

Laura M. Drudi, MD, from Jewish General Hospital in Montreal, and colleagues assessed depressive symptoms in preplanned analysis of the Frailty Aortic Valve Replacement prospective cohort study (14 centers in 3 countries from November 15, 2011, through April 7, 2016). Participants included individuals (mean age, 81.4 years) who underwent TAVR or SAVR aortic valve replacement.

Among 1035 participants, the researchers found that 31.5% had a positive screening result for depression, but only 8.6% had depression documented in their clinical record. 

Baseline depression was associated with mortality at 1 month (odds ratio, 2.20) and at 12 months (odds ratio, 1.532), after adjusting for clinical and geriatric confounders. There was a 3-fold increase in mortality at 12 months (odds ratio, 2.98) among participants with persistent depression (still present 6 months after the procedure).

"One in three older adults undergoing TAVR or SAVR had depressive symptoms at baseline and a higher risk of short-term and midterm mortality," the authors wrote. "Patients with persistent depressive symptoms at follow-up had the highest risk of mortality."

Disclosures: Several authors disclosed financial ties to the pharmaceutical industry.

Reference

Crudi LM, Ades M, Turkdogan S, et al. Association of depression with mortality in older adultsundergoing transcatheter or surgical aortic valve replacement [published online January 17, 2018]. JAMA Cardiol. doi:10.1001/jamacardio.2017.5064

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