HealthDay News — Allopurinol does not appear to improve exercise capacity or peripheral endothelial or coronary function in patients with cardiac syndrome X, according to a study published in Cardiovascular Therapeutics.

Tiong Keng Lim, MD, from National Heart Centre Singapore, and colleagues randomized 19 patients with cardiac syndrome X (mean age 59 years) to 6 weeks of treatment with either allopurinol (600mg/day) or placebo. Patients were crossed over to the other study arm after a 4-week washout period.

The researchers found that allopurinol significantly reduced serum uric acid levels vs placebo. 

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There was no significant difference in maximum exercise time, coronary flow reserve, or flow-mediated vasodilatation of the brachial artery between the allopurinol and placebo groups. However, there was a trend toward allopurinol reducing serum B-type natriuretic peptide compared with placebo (P = .07).

“In patients with cardiac syndrome X, high dose allopurinol did not improve exercise capacity, coronary or peripheral endothelial function,” conclude the authors.

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Lim TK, Noman A, Choy AMJ, et al. The APEX trial: Effects of allopurinol on exercise capacity, coronary and peripheral endothelial function, and natriuretic peptides in patients with cardiac syndrome X [published online November 26, 2017]. Cardiovasc Ther. doi: 10.1111/1755-5922.12311