HealthDay News — The prophylactic use of low-dose oxygen does not reduce death or disability at 3 months among patients with acute stroke, according to a study published in the Journal of the American Medical Association.

Christine Roffe, MD, from the University Hospital of North Midlands NHS Trust in Stoke-on-Trent, UK, and colleagues conducted a single-blind randomized trial involving 8003 adults with acute stroke enrolled within 24 hours of hospital admission if they had no indications for or contradictions to oxygen treatment. Participants were randomly allocated to continuous oxygen for 72 hours (2668 patients), nocturnal oxygen for 3 nights (2667 patients), or control (oxygen if clinically indicated, 2668 patients).

The researchers found that the unadjusted odds ratio for a better outcome was 0.97 (95% confidence interval, 0.89 to 1.05; P =.47) for oxygen vs control; and for continuous vs nocturnal oxygen, the odds ratio was 1.03 (95% confidence interval, 0.93 to 1.13; P =.61). No subgroup was found to benefit from oxygen. At least 1 serious adverse event occurred in 13.0%, 11.0%, and 12.1% of participants in the continuous oxygen group, nocturnal group, and the control group, respectively.

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“Among nonhypoxic patients with acute stroke, the prophylactic use of low-dose oxygen supplementation did not reduce death or disability at three months,” the authors write.

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Roffe C, Nevatte T, Sim J, et al. Effect of routine low-dose oxygen supplementation on death and disability in adults with acute stroke: the stroke oxygen study randomized clinical trial. JAMA. doi: 10.1001/jama.2017.11463