Link Between CVD Risk and Idiopathic Thrombocytopenic Purpura Examined

Immune thrombocytopenic purpura
Immune thrombocytopenic purpura
There is an increased risk of developing cardiovascular disease among patients with idiopathic thrombocytopenic purpura, especially those who undergo splenectomy.

HealthDay News — There is an increased risk of developing cardiovascular disease (CVD) in patients with idiopathic thrombocytopenic purpura (ITP), especially those who undergo splenectomy, according to a study published online in the Journal of Thrombosis and Haemostasis.

Joht Singh Chandan, MBBS, from Queen Elizabeth Hospital in Birmingham, UK, and colleagues used data from 6591 patients with ITP and 24,275 controls matched by age, sex, body mass index, and smoking status.

The groups were compared with respect to the risk for CVD, including ischemic heart disease, stroke, transient ischemic attack, and heart failure.

The researchers found that over a median 6-year period there were 392 CVD diagnoses in ITP patients (5.9%) and 1114 diagnoses in controls (4.5%).

The elevated risk of developing CVD in the ITP cohort (adjusted incidence rate ratio [IRR], 1.38) remained even after a sensitivity analysis which included only incident cases of ITP. The risk of developing CVD was further elevated in patients who underwent splenectomy (adjusted IRR, 1.69).

“Physicians should routinely evaluate for cardiovascular symptoms and manage risk factors for cardiovascular disease optimally in patients with ITP,” the authors wrote. “Decision on offering splenectomy to patients with ITP should take into consideration future increased risk of cardiovascular disease.”

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Chandan JS, Thomas T, Lee S, Marshall T, Willis B, Nirantharakumar K. The association between idiopathic thrombocytopenic purpura and cardiovascular disease: a retrospective cohort study [published online January 3, 2018]. J Thromb Haemost. doi:10.1111/jth.13940