In the ODYSSEY ESCAPE trial, patients with heterozygous familial hypercholesterolemia were given either the PCSK9-inhibitor alirocumab or placebo for 18 weeks to determine if they could reduce their use of the lipoprotein apheresis.

While apheresis is effective at lowering LDL-C in these patients, it is invasive and requires 2 to 3 hours to administer every week or every 2 weeks.

Study investigator Patrick M. Moriarty of the University of Kansas Medical Center in Kansas City discusses the trial findings with European Heart Journal editor-in-chief, Thomas Lüscher and atherosclerosis expert, Gerald Watts of the University of Western Australia at the 2016 European Society of Cardiology congress.

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Moriarty PM, Parhofer KG, Babirak SP, et al. Alirocumab in patients with heterozygous familial hypercholesterolemia undergoing lipoprotein apheresis: the ODYSSEY ESCAPE trial. Eur Heart J. 2016. doi:10.1093/eurheartj/ehw388.