HealthDay News – Dietary glycemic index (GI) is associated with lung cancer risk, according to a study published in the March issue of Cancer Epidemiology, Biomarkers & Prevention.

Stephanie C. Melkonian, PhD, from the University of Texas MD Anderson Cancer Center in Houston, and colleagues assessed glycemic load (GL) and GI among 1905 newly diagnosed lung cancer cases and 2413 healthy controls. The correlations between quintiles of GI/GL and lung cancer risk were assessed.

Researchers observed a significant correlation between GI and lung cancer risk (fifth vs first quintile, odds ratio [OR]: 1.49; Ptrend <.001). There was also a significant correlation between total GI using total available carbohydrate and lung cancer risk (fifth vs first quintile, OR: 1.48; Ptrend =.001). The correlations for GI and lung cancer risk were more pronounced among never smokers (OR: 2.25), for squamous cell carcinoma (OR: 1.92), and for those with less than 12 years of education (OR: 1.75).

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“Understanding the role of GI in lung cancer could inform prevention strategies and elucidate biologic pathways related to lung cancer risk,” the authors wrote.


Melkonian SC, Daniel CR, Ye Y, Pierzynski JA, Roth JA, Wu X. Glycemic index, glycemic load, and lung cancer risk in non-Hispanic whites. Cancer Epidemiol Biomark Prev. 2016. doi: 10.1158/1055-9965.EPI-15-0765.