(HealthDay News) – For patients with type 1 diabetes mellitus (T1DM), severe hypoglycemia is associated with increased risk of all-cause mortality and cardiovascular disease (CVD), according to research published in Diabetes Care.

Chin-Li Lu, from the National Cheng Kung University in Tainan, Taiwan, and colleagues examined the effects of severe hypoglycemia on risks of all-cause mortality and CVD incidence in 2 nested case-control studies conducted within a cohort of 10 411 patients with T1DM in Taiwan. A total of 564 non-survivors and 1615 controls and 743 CVD cases and 1439 controls were enrolled between 1997 and 2011. The history of severe hypoglycemia was examined during 1 year, 1 to 3 years, and 3 to 5 years before the study outcomes.

The researchers found that the risks of all-cause mortality and CVD were elevated with prior severe hypoglycemic events within 1 year (adjusted odds ratios: 2.74 and 2.02, respectively). Correlations were also seen for events occurring within 1 to 3 and 3 to 5 years before death (adjusted odds ratios: 1.94 and 1.68, respectively). Within 5 years there were significant dose-gradient effects of severe hypoglycemia frequency on mortality and CVD.


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“Although the CVD incidence may be associated with severe hypoglycemic events occurring in the previous year, the risk of all-cause mortality was associated with severe hypoglycemic events occurring in the preceding five years,” the authors write.

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Reference

Lu CL, Shen HN, Hu SC. A population-based study of all-cause mortality and cardiovascular disease in association with prior history of hypoglycemia among patients with type 1 diabetes. Diabetes Care. 2016; doi: 10.2337/dc15-2418.