HealthDay News – A brief, partly web-based educational intervention, HypoAware, is beneficial for reducing severe hypoglycemic episodes and improving hypoglycemia awareness compared with usual care, according to a study published online in Diabetes Care.

Stefanie MPA Rondags, from the VU University Medical Center in Amsterdam, and colleagues enrolled 137 insulin-treated patients with problematic hypoglycemia in 8 Dutch clinics to compare HypoAware care with usual care. The authors assessed self-reported severe hypoglycemia, impaired hypoglycemia awareness, and worries and distress about hypoglycemia at baseline and at 2, 4, and 6 months of follow-up.

The researchers found that, compared with the control group, the HypoAware group had 33% fewer episodes of severe hypoglycemia (relative risk [RR]: 0.67; 95% confidence interval [CI], 0.39-1.16). They also had significantly reduced odds of impaired awareness (odds ratio: 0.38; 95% CI, 0.15-0.95), a trend toward fewer worries about hypoglycemia (RR: 0.80; 95% CI, 0.64-1.01), and a significant reduction in hypo-distress (RR: 0.70; 95% CI, 0.56-0.88). Participants experienced a median of 2.5 events of severe hypoglycemia in the control condition vs one event in the HypoAware event over the 6-month study duration (P =.030).

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“HypoAware resulted in fewer severe hypoglycemic episodes, significantly improved hypoglycemia awareness, and less hypo-distress in comparison with usual care, and deserves further dissemination,” the authors wrote.

Disclosures: The study was partially funded by Novo Nordisk and Agis Achmea, a Dutch health care insurer.


Rondags SFMPA, de Wit M, Twisk JW, Snoek FJ. Effectiveness of HypoAware, a brief partly web-based pyschoeducational intervention for adults with type 1 and insulin-treated type 2 diabetes and problematic hypoglycemia: a cluster randomized controlled trial. Diabetes Care. 2016 Oct 31. doi:10.2337/dc16-1614 [Epub ahead of print].