HealthDay News – For patients with type 2 diabetes, the lowest glucose variability (GV) and hypoglycemia is seen for patients using basal insulin + glucagon-like peptide 1 receptor agonist (GLP-1 RA) (BGLP), according to a study published online in Diabetes Care.

Harpreet S. Bajaj, MD, MPH, from LMC Diabetes & Endocrinology in Brampton, Canada, and colleagues compared GV using continuous glucose monitoring (CGM) in patients with well-controlled type 2 diabetes using 4 insulin regimens: basal insulin + oral drugs (BO), BGLP, premixed insulin (PM), and basal-bolus insulin (BB). One hundred sixty patients underwent 6-day masked CGM in 4 equal insulin regimen cohorts.

The researchers found that the primary outcome of the daily glucose standard deviation was significantly lower in the BGLP cohort compared with the BO (P =.03), PM (P =.01), and BB (P <.01) cohorts; these correlations persisted after adjustment for age, body mass index, type 2 diabetes duration, and hemoglobin A1c. The BGLP cohort had the lowest daily hypoglycemia outcomes on CGM.

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“These observed benefits in GV and hypoglycemia may contribute to the cardiovascular outcome reduction seen with GLP-1 RA therapy and should be investigated further,” the authors wrote.

Disclosures: Several authors disclosed financial ties to the pharmaceutical industry.


Bajaj HS, Venn K, Ye C, et al. Lowest glucose variability and hypoglycemia are observed with the combination of a GLP-1 receptor agonist and basal insulin (VARIATION study) [Published online December 2, 2016]. Diabetes Care. doi:10.2337/dc16-1582.