Patients with type 2 diabetes who did not take statins had better glycemic control but had higher risk for mortality, according to the results of a retrospective cohort study presented at the American Diabetes Association (ADA) 77th Scientific Sessions, held in San Diego, California.

Researchers from Nottingham, United Kingdom, collected data from a large UK Primary Care database of patients (n=18,227) who had initiated insulin in routine care (mean age, 61.5±13.6 years). They compared changes in hemoglobin A1c (HbA1c) levels at 6, 12, 24, and 36 months, as well as the 5-year risk for mortality between patients taking statins (n=15,799) and patients who were not taking statins (N=2428).

 


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At baseline, both groups had similar A1c levels (≈8.6%). At 6 months, patients who took statins had HbA1c levels of ≈8.4%, whereas patients who were not taking statins had A1c levels of ≈8.3%. At 12 months, HbA1c levels in patients who were not taking statins were ≈8.2% vs ≈8.4% in patients taking statins. At 24 months, patients not taking statins actually saw an increase in HbA1c levels, whereas the patients taking statins maintained a similar level from the last follow-up. However, at 36 months, the patients not taking statins had lower HbA1c levels compared with the patients who were taking statins.

Although there was a greater reduction in HbA1c after insulin initiation in patients who did not use statins, the all-cause mortality was lower among patients who did take statins (adjusted hazard ratio, 1.63; 95% CI, 1.46-1.82; P <.0001). 

Disclosures: Drs Idris and Donnelly report financial relationships with Novo Nordisk, Eli Lilly and Company, AstraZeneca, and Boehringer Ingelheim.

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Reference

Anyanwagu UC, Mamza JB, Idris I, Donnelly R. Use of statins in patients with insulin-treated type 2 diabetes (T2D): associations with glycemic control and mortality risks. Presented at: American Diabetes Association (ADA) 77th Scientific Sessions; June 9-13, 2017; San Diego, CA. Abstract 1619-P.