HealthDay News — Individuals using statins may be at higher risk for hyperglycemia, insulin resistance, and eventually type 2 diabetes, according to a study published online March 5 in the British Journal of Clinical Pharmacology.

Fariba Ahmadizar, Ph.D., from the Erasmus University Medical Centre in the Netherlands, and colleagues used data from the prospective population-based Rotterdam Study to identify 9,535 individuals free from diabetes at baseline (mean age, 64.3 years; 41.7 percent male) who were evaluated between 1997 and 2012.

The researchers found that in a fully adjusted model, baseline use of statins was associated with higher concentrations of serum fasting insulin and insulin resistance compared with never users of statins. A 38 percent higher risk for incident type 2 diabetes was seen with ever use of statins (hazard ratio, 1.38). This risk was stronger among patients with impaired glucose homeostasis and in overweight/obese individuals.


Continue Reading

“Rigorous preventive strategies such as glucose control and weight reduction in patients when initiating statin therapy might help minimize the risk of diabetes,” the authors write.

Abstract/Full Text

Related Articles