Cardiometabolic Effects of Gender-Affirming Hormone Therapy in Transgender Youth
Transgender youth on gender-affirming hormone therapy have differences in their percent fat and lean mass compared with cisgender youth.
Dyslipidemia
DYSLIPIDEMIA
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Clinical Features Can Differentiate FCS From Severe Hypertriglyceridemia
Several clinical features can be accurate in differentiating between familial chylomicronemia syndrome and severe hypertriglyceridemia.
Residual Hypertriglyceridemia With Statin Treatment Common in Diabetes
One-third of patients with diabetes and HTG overall and approximately 40% of statin users were found to be at high long-term cardiovascular risk.
Childhood Statin Initiation Reduced Adult CVD Risk in Familial Hypercholesterolemia
Initiation of statin therapy during childhood in patients with familial hypercholesterolemia slows the progression of CIMT and reduces the risk for CVD over 20 years.
Polypill Regimen Reduces Blood Pressure, LDL-C in Underserved Patients
Compared with usual care, a polypill regimen led to greater reductions in systolic blood pressure and low-density lipoprotein cholesterol level in socioeconomically vulnerable minority patients.
Inclisiran Benefits Patients With Familial Hypercholesterolemia and ASCVD
Inclisiran is a chemically synthesized small interfering RNA (siRNA) that targets proprotein convertase subtilisin-kexin type 9 (PCSK9) messenger RNA.
More Aggressive Treatment Needed for Familial Hypercholesterolemia
Even with care in specialty clinics, LDL-C persists above target levels in more than half of patients with familial hypercholesterolemia.
Lipid-Lowering Therapy May Reduce Need for AVR in Mild Aortic Stenosis
Investigators examined whether pretreatment low-density lipoprotein cholesterol levels and aortic stenosis severity affect lipid-lowering therapy to decrease aortic valve replacement.
Elevated Triglycerides Linked to Worse CV and Health Economic Outcomes
Researchers used using observational administrative claims data from the Optum Research Database to retrospectively examine the real-world effect of elevated triglyceride levels on cardiovascular outcomes and medical cost.
High LDL-C Not Causally Linked to Risk for Retinopathy and Neuropathy
Investigators analyzed whether high LDL-C causally relates to risk for retinopathy, neuropathy, chronic kidney disease, and peripheral artery disease in the general population.
Evolocumab Rapidly Reduces LDL-C When Added to High-Intensity Statin in ACS
Researchers evaluated how feasible, safe, and effective evolocumab is at lowering low-density lipoprotein cholesterol when initiated in patients hospitalized with acute coronary syndrome.
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