HealthDay News – A culturally-tailored stepwise diabetes prevention program can reduce incidence of diabetes among overweight/obese Asian Indian adults, according to a study published online August 8 in Diabetes Care.

Mary Beth Weber, PhD, MPH., from Emory University in Atlanta, and colleagues conducted a randomized trial involving 578 overweight/obese Asian Indian adults with isolated impaired glucose tolerance (iIGT), isolated impaired fasting glucose (iIFG), or IFG+IGT. 

Patients were randomized to standard lifestyle advice or to a 6-month culturally-tailored US Diabetes Prevention Program-based lifestyle curriculum plus addition of metformin for those at highest risk of conversion to diabetes.

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Researchers found that 34.9% of control and 25.7% of intervention patients developed diabetes during 3 years of follow-up (P=.014). The relative risk reduction (RRR) was 32%; in order to prevent 1 case of diabetes, the number needed to treat was 9.8. 

There was variation in RRR by prediabetes type (IFG+IGT, 36%; iIGT, 31%; and iIFG, 12%); patients aged 50 years or older, males, and obese had stronger RRR. In addition to lifestyle, 72% of patients also required metformin; however, there was some variability by prediabetes type (iIFG, 76.5%; IFG+IGT, 83.0%; iIGT, 51.3%).

“Stepwise diabetes prevention in people with prediabetes can effectively reduce diabetes incidence by a third in community settings; however, people with iIFG may require different interventions,” the authors wrote.

Disclosures: The study was supported by a BRiDGES grant, which was funded by Lilly Diabetes.


Weber MB, RanJani H, Staimez LR, et al. The stepwise approach to diabetes prevention: results from the D-CLIP randomized controlled trial. Diabetes Care. 2016. doi:10.2336/dc16-1241.