In-hospital mortality in patients with type 1 diabetes admitted for acute myocardial infarction (AMI) was significantly higher compared with patients with type 2 diabetes, according to a retrospective cohort study presented at the 26th Annual Scientific & Clinical Congress of the American Association of Clinical Endocrinologists (AACE), May 3-7, in Austin, Texas.
Researchers from Mount Sinai West and Mount Sinai St. Luke’s in New York City included 226,956 patients from the 2013 National Inpatient Sample. Almost 98% of these patients (n=221,310) had type 2 diabetes and 2.5% had type 1 diabetes (n=5,655).The mean age of the total population was 67.38, but by group the mean age was lower in patients with type 1 diabetes (57.8).
When compared with patients with type 2 diabetes, patients with type 1 diabetes had an increased adjusted inpatient mortality rate (odds ratio 1.49; 95% CI, 1.12-1.99; P <.01). Patients with type 1 diabetes also had a longer length of hospital stay by 0.5 days (P =.02). Hospital costs, however, were not statistically significant between groups.
“There has been conflicting evidence when comparing cardiovascular mortality in patients with [type 1 diabetes] and [type 2 diabetes],” the researchers wrote. “Despite this, [type 1 diabetes] has been shown to cause earlier endothelial damage and autonomic dysinnervation causing impaired vasodilator response of coronary vessels when compared [with] patients with [type 2 diabetes].”
Vallejo F, Hurtado C, Lopez K, Garcia R, Albu J. In-hospital mortality in patients admitted for acute myocardial infarction: type 1 diabetes mellitus compared to type 2 diabetes mellitus. Abstract 289. Presented at: the 26th Annual Scientific & Clinical Congress of the American Association of Clinical Endocrinologists. May 3-7, 2017; Austin, TX.
This article originally appeared on Endocrinology Advisor