HealthDay News – Coronary computed tomography angiography (CCTA) is associated with more appropriate use of invasive angiography and increased use of preventive therapies, according to a study published online April 11 in the Journal of the American College of Cardiology.

Michelle C. Williams, MD, from the University of Edinburgh in the United Kingdom, and colleagues used data from a trial of 4146 patients who were randomized to receive standard care or CCTA. Dr Williams and her team sought to examine changes in invasive coronary angiography, preventive treatments, and clinical outcomes.

Researchers found that the rates of invasive angiography were similar for those randomized to CCTA and standard care (P=.451); however, those allocated to CCTA were less likely to demonstrate normal coronary arteries on invasive angiography (20 vs 56; hazard ratio [HR]: 0.39) and more likely to show obstructive coronary artery disease (283 vs 230; HR: 1.29). 


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After CCTA, more preventive therapies were initiated (283 vs 74; HR: 4.03). Fatal and nonfatal myocardial infarction was halved in patients allocated to CCTA vs standard care (17 vs 34; HR: 0.50), from the median time for preventive therapy initiation (50 days).

“In patients with suspected angina due to coronary heart disease, CCTA leads to more appropriate use of invasive angiography and alterations in preventive therapies that were associated with a halving of fatal and non-fatal myocardial infarction,” the authors wrote.

Disclosures: Several authors disclosed financial ties to the biopharmaceutical industry.

References

  1. Min JK, Jones EC, Pe JM. The future from the past. A chance for change. J Am Coll Cardiol. 2016;67(15):1769-1771. doi:10.1016/j.jacc.2016.02.028.
  2. Williams MC, Hunter A, Shah ASV, et al. Use of coronary computed tomographic angiography to guide management of patients with coronary disease. J Am Coll Cardiol. 2016;67(15):1759-1768. doi:10.1016/j.jacc.2016.02.026.