HealthDay News — Continuous positive airway pressure (CPAP) and mandibular advancement devices (MADs) each produce a modest reduction in both systolic and diastolic blood pressure (BP) rates in patients with obstructive sleep apnea, according to a meta-analysis published in the December 1 issue of the Journal of the American Medical Association.

Malcolm Kohler, MD, chair of respiratory medicine at the University Hospital of Zurich, and colleagues looked at the ability of CPAP and MADs to lower BP in 51 previously published studies that included a total of 4888 patients.

The researchers found that CPAP was associated with a reduction in systolic BP of 2.5 mm Hg, and a reduction of 2.0 mm Hg in diastolic BP. MADs were associated with a reduction of 2.1 and 1.9 mm Hg in systolic and diastolic BP, respectively. Although no statistically significant difference between CPAP and MADs in lowering BP was found, CPAP was more likely to have a strong association with lowering systolic BP, Dr Kohler said.

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“CPAP and MADs not only reduce symptoms of obstructive sleep apnea such as sleepiness, but also lower blood pressure,” Dr Kohler said. “Both treatments have similar positive effects on blood pressure, but the treatment effect of CPAP seems to be larger in patients who have more hours of sleep.”


Bratton DJ, Gaisl T, Wons AM, Kohler M. CPAP vs mandibular advancement devices and blood pressure in patients with obstructive sleep apnea. JAMA. 2015;314(21):2280-2293. doi:10.1001/jama.2015.16303.