Heart Failure With Preserved vs Reduced Ejection Fraction Hospitalization Trends

HealthDay News – Heart failure with preserved ejection fraction (HFpEF) is common among patients hospitalized with acute heart failure, and patients with HFpEF are older, more often female, and frequently have comorbidities, according to a study published in the June issue of The American Journal of Medicine.

Parag Goyal, MD, from the Weill Cornell Medical College in New York City, and colleagues examined 5,046,879 hospitalizations with a diagnosis of acute heart failure in 2003 to 2012 from the Nationwide Inpatient Sample. Hospitalizations were stratified by HFpEF and heart failure with reduced ejection fraction (HFrEF).

Researchers found that those with HFpEF were older, more often female, and more likely to have hypertension, atrial fibrillation, chronic lung disease, chronic renal failure, and anemia compared to those with HFrEF. HFpEF accounted for increasing proportions of men and patients aged 75 years and older over time. There was a 13% decrease in the in-hospital mortality rate, mainly due to improved survival in those aged 65 years or older.

Pulmonary circulation disorders, liver disease, and chronic renal failure were independent predictors of in-hospital mortality, in multivariable regression analyses; inverse associations were seen for treatable diseases, including hypertension, coronary artery disease, and diabetes.

“Examination of a national representative sample of US hospital discharges yielded identification of over 2 million hospitalizations with HFpEF, representing the largest cohort of HFpEF to date,” the authors wrote.

Disclosures: One author disclosed financial ties to the pharmaceutical industry.


Goyal P, Almarzooq ZI, Horn EM, et al. Characteristics of hospitalizations for heart failure with preserved ejection fraction. Am J Med. 2016;129(6):635.e15-635.e26. doi: 10.1016/j.amjmed.2016.02.007.