HealthDay News – For patients with heart failure with reduced ejection fraction (HFrEF), angina pectoris (AP) is associated with worse health-related quality of life (HRQoL) and depressive symptoms, according to a study published in The American Journal of Cardiology.

Kishan S. Parikh, MD, from the Duke Clinical Research Institute in Durham, North Carolina, and colleagues grouped 2331 patients with HFrEF from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training trial according to whether they had self-reported AP by Canadian classification score. HRQoL and clinical outcomes by AP status were examined.

The researchers found that 406 patients (17%) had AP at baseline; the severity of heart failure was similar to those without AP. Baseline exercise capacity was similar for patients with AP, but depressive symptoms and HRQoL were worse. AP correlated with a 22% increased adjusted risk for all-cause mortality/hospitalizations, which was driven by hospitalizations. Baseline AP was significantly associated with exercise training peak maximum volume of oxygen (VO2) change (P =.019); there were no correlations for other end points. In patients with AP, exercise training correlated with greater peak VO2 improvements after three months (treatment effect = 1.25 ml/kg/min).

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“AP was associated with worse HRQoL and depressive symptoms,” the authors wrote. “Despite greater peak VO2 improvement with exercise training, patients with AP experienced more adverse outcomes.”

Disclosures: Several authors disclosed financial ties to the pharmaceutical industry.


Parikh KS, Coles A, Schulte PJ, et al. Relation of angina pectoris to outcomes, quality of life, and response to exercise training in patients with chronic heart failure (from HF-ACTION). Am J Cardiol. 2016;118(8):1211-1216. doi:10.1016/j.amjcard.2016.07.040.