Rosuvastatin vs Atorvastatin in Regression of Coronary Atherosclerotic Plaques

HealthDay News — Rosuvastatin appears to be more effective than atorvastatin for regression of coronary atherosclerotic plaques, according to a meta-analysis published in the November 15 issue of The American Journal of Cardiology.

Cheng Qian, MD, from Zhongnan Hospital of Wuhan University in China, and colleagues conducted a meta-analysis to provide evidence for proper statin selection for the reversion of coronary atherosclerotic plaques. Five randomized trials that met predefined inclusion criteria were analyzed, with a total of 1556 participants, of whom 772 were in the rosuvastatin group and 784 in the atorvastatin group.

In all included trials, the dose ratios of rosuvastatin versus atorvastatin were 1:2. The researchers found that rosuvastatin administration further reduced the total atheroma volume (P=.004) and percent atheroma volume (P=.03), compared with atorvastatin, and correlated with more improvement in lumen volume (P=.046). There was no difference in the comparative regression of plaques across subgroups.

“In conclusion, rosuvastatin is superior to atorvastatin in the reversion of coronary atherosclerotic plaques,” the authors wrote.

Qian C, Wei B, Ding J, et al. Meta-analysis Comparing the Effects of Rosuvastatin Versus Atorvastatin on Regression of Coronary Athersclerotic Plaques. Am J Cardiol. 2015;116(10):1521-1526. doi: http://dx.doi.org/10.1016/j.amjcard.2015.08.010.