HealthDay News – Serum growth differentiation factor 15 (GDF-15) levels are associated with coronary artery disease (CAD), according to a study published online March 21 in Cardiovascular Therapeutics.

Xia Wang, from the Nanjing Medical University in China, and colleagues examined serum GDF-15 levels and predictive values in patients with CAD. The enzyme-linked immunosorbent assay was used to measure serum levels of GDF-15 in 105 CAD patients and 96 healthy controls. CAD severity was assessed with Gensini scores; the correlations between serum GDF-15 levels and Gensini scores were assessed.

Researchers found that serum GDF-15 levels were significantly increased in patients with CAD vs the healthy group (P<.001). There was a positive correlation between GDF-15 and Gensini score (r=0.85; P<.001). The area under the receiver operating characteristic curve analysis result was 0.96 (P<.001); serum GDF-15 levels had sensitivity and specificity of 80.0% and 91.7%, respectively, for predicting CAD.

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“These data suggested that increased GDF-15 levels were positively associated with CAD, and GDF-15 might be a useful adjunct in discriminating CAD,” the authors wrote.


Wang X, Chen L-L, Zhang Q. Increased serum level of growth differentiation factor 15 (GDF-15) is associated with coronary artery disease. Cardiovasc Ther. 2016. doi: 10.1111/1755-5922.12184.