Greater levels of a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS-9) were found to be associated with greater risk for major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI), according to a study published in Angiology.

Researchers assessed the level of ADAMTS-9 in 666 patients (without coronary artery disease [CAD]: n=214; mean age, 57.1 ± 14.3 years; 55.1% men; with CAD: n=452; mean age, 60.0 ± 11.4 years; 75.2% men) who underwent coronary angiography. Patients with CAD were divided into those with stable angina pectoris (SAP), unstable angina, non–ST-segment elevation myocardial infarction (NSTEMI), or STEMI.

All participants were continuously followed up until the first major adverse cardiovascular event (MACE), for up to 2 years (mean, 12 months; interquartile range, 12 months). There was a greater prevalence of hypertension, diabetes, and smoking and lower use of antidiabetic drugs in patients with vs without CAD.


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Serum level of ADAMTS-9 was higher in patients with vs without CAD (37.53 ± 8.55 ng/mL vs 12.04 ± 7.02 ng/mL, respectively; P <.001) and was found to be an independent predictor of CAD (odds ratio, 1.871; 95% CI, 1.533-2.283; P <.001). Among patients CAD, those with acute coronary syndrome (ACS) had higher serum levels of ADAMTS-9 compared with patients with SAP.

ADAMTS-9 levels were found to be correlated with the SYNTAX score (r = 0.523; P <.001). Patients with AMI and increased vs lower levels of ADAMTS-9 had a higher risk for MACE within 12 months (log-rank = 4.490; P =.034).

Study limitations include its single-center, cross-sectional, and retrospective design, short follow-up period, and limited cohort.

“This study supports that the level of ADAMTS-9 is associated with the severity of CAD and the prognosis of patients with AMI,” the researchers concluded. “Further research on ADAMTS-9 is needed to clarify its role in the pathogenesis of atherosclerosis and potentially improve the prevention and treatment of CAD and atherosclerosis.”

Reference

Wei M, Pan H, Guo K. Association between plasma ADAMTS-9 levels and severity of coronary artery disease [published online December 14, 2020]. Angiology. doi: 10.1177/0003319720979238