HealthDay News – ASGR1 mutation carriers have reduced levels of non-high-density lipoprotein cholesterol (HDL-C) and reduced risk of coronary artery disease, according to a study published online May 18 in the New England Journal of Medicine.
Paul Nioi, PhD, from deCODE Genetics-Amgen in Reykjavik, Iceland, and colleagues sequenced the genomes of 2636 Icelanders and identified variants that they imputed into the genomes of about 398 000 Icelanders. They examined the correlation between the imputed variants and non-HDL-C levels in 119 146 samples, and assessed the effects of an implicated loss-of-function variant on the risk of coronary artery disease in 42 524 case patients and 249 414 controls from populations of European ancestry.
Researchers identified a rare noncoding 12-base-pair deletion (del12) in intron 4 of ASGR1, encoding a subunit of the asialoglycoprotein receptor. The del12 mutation activated a cryptic splice site, which led to a frameshift mutation and premature stop codon, rendering a degradation-prone truncated protein.
Compared with noncarriers, heterozygous carriers of the mutation had a lower level of non-HDL cholesterol and a 34% lower risk of coronary artery disease. Another loss-of-function ASGR1 variant that correlated with lower levels of non-HDL-cholesterol was identified in a larger set of sequenced samples.
“ASGR1 haploinsufficiency was associated with reduced levels of non-HDL cholesterol and a reduced risk of coronary artery disease,” the authors wrote.
Disclosures: The study was partially funded by Novo Nordisk; several authors were employed by deCODE Genetics-Amgen.
- Nioi P, Sigurdsson A, Thorleifsson G, et al. Variant ASGR1 associated with a reduced risk of coronary artery disease. N Engl J Med. 2016. doi: 10.1056/NEJMoa1508419.
- Tybjaerg-Hansen A. The Sialylation pathyway and coronary artery disease. N Engl J Med. 2016. doi: 10.1056/NEJMe1604773.