HealthDay News – The ventricular ectopic QRS interval (VEQSI) can identify post-myocardial infarction (MI) patients with prior serious ventricular arrhythmia, according to a study published online June 1 in JACC: Clinical Electrophysiology.
Rachel Bastiaenen, PhD, from St. George’s University Hospitals NHS Foundation Trust in London, and colleagues analyzed 12-lead Holter recordings from 189 patients with previous MI: 38 with prior life threatening events (MI-ventricular tachycardia [VT]/ventricular fibrillation [VF]) and 151 without prior significant ventricular arrhythmia (MI-no VT/VF). Results were compared with those from 60 healthy controls. All ventricular ectopic beats (VEB) were reviewed; the duration of the longest VEB was recorded as VEQSI max.
Researchers found that VEQSI max was longer in post-MI patients than healthy controls, and in MI-VT/VF patients with prior life threatening events than in MI-no VT/VF patients without prior life threatening events (both P <.001). VEQSI max was established as the strongest independent marker for prior serious ventricular arrhythmia in multivariate analysis. For identifying patients with prior life threatening events, VEQSI max >198 ms had 86% sensitivity, 85% specificity, 62% positive predictive value, and 96% negative predictive value (odds ratio: 37.4).
“This may be a useful additional index for risk stratification in ischemic heart disease,” the authors wrote.
Disclosures: One author disclosed financial ties to Boston Scientific and Medtronic; Boston Scientific partially funded the study.
Bastiaenen R, Gonna H, Chandra N, et al. The ventricular ectopic QRS interval. A potential marker for ventricular arrhythmia in ischemic heart disease. JACC Clin Electrophysiol. 2016. doi: 10.1016/j.jacep.2016.04.005.