HealthDay News – For patients with atrial fibrillation (AF) and left ventricular systolic dysfunction, cardiomyopathy etiology impacts long-term outcomes of catheter ablation, according to a study published online December 28 in the Journal of Cardiovascular Electrophysiology.

Sandeep Prabhu, MBBS, from Alfred Hospital in Melbourne, Australia, and colleagues examined the impact of cardiomyopathy etiology on long-term outcomes following catheter ablation for AF. Participants included 101 patients with known heart disease as a cause of cardiomyopathy (KHD; 77 patients) and idiopathic dilated cardiomyopathy (IDCM; 24 patients). The patients had left ventricular ejection fraction (LVEF) <45% and underwent AF ablation from 2002 to 2014.

The researchers found that AF control was greater in the IDCM group after a mean follow-up of 36 ± 23 months (82% vs 50% in KHD; P<.01). IDCM correlated with long-term AF control on multivariate analysis (P=.033). At follow-up, the IDCM group had less functional impairment (P=.005) and improved LVEF (P<.001). Super responders, with EF improvement >15%, were mainly found in the IDCM group (94% vs 6%; P<.001), with greater AF control (89% vs 61%; P<.001). The KHD group had significantly higher all-cause mortality (17% vs 1.3%; P=.002).

Continue Reading

“IDCM was associated with greater AF control, and improvement in symptoms and LVEF compared to patients with KHD post AF ablation,” the authors wrote.

Disclosures: One author disclosed financial ties to the medical device and medical technology industries.


Prabhu S, Ling LH, Ullah W, et al. The impact of known heart disease on long-term outcomes of catheter ablation in patients with atrial fibrillation and left ventricular systolic dysfunction: a multicenter international study. J Cardiovasc Electrophysiol. 2015. DOI: 10.1111/jce.12899.