HealthDay News — For patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), there were fewer target lesion failures at one year in those receiving biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents, according to a study published online Sept. 2 in The Lancet. The research was published to coincide with the European Society of Cardiology Congress 2019, held from Aug. 31 to Sept. 4 in Paris.

Juan F. Iglesias, M.D., from Geneva University Hospitals and colleagues conducted a randomized clinical trial in patients with acute STEMI undergoing primary PCI. A total of 1,300 patients were randomly assigned to receive either biodegradable polymer sirolimus-eluting stents (649 patients with 816 lesions) or durable polymer everolimus-eluting stents (651 patients with 806 lesions).

The researchers found that the primary composite end point of target lesion failure occurred in 4 and 6 percent of patients treated with biodegradable polymer sirolimus-eluting stents and durable polymer everolimus-eluting stents, respectively (difference, −1.6 percentage points; rate ratio, 0.59; posterior probability of superiority, 0.986). In the 12 months of follow-up, cardiac death, target vessel myocardial reinfarction, clinically indicated target lesion revascularization, and definite stent thrombosis were similar between the treatment groups.

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“In the present study, the difference in the primary end point between the two study groups was largely driven by fewer cases of clinically-indicated target lesion revascularization in patients treated with biodegradable polymer sirolimus-eluting stents compared with durable polymer everolimus-eluting stents,” the authors write.

Several authors disclosed financial ties to pharmaceutical and medical device companies, including Biotronik, which funded the study.

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