Significant QT Prolongation Associated With Chloroquine/Hydroxychloroquine Treatment for COVID-19
The treatment of patients with COVID-19 with chloroquine or hydroxychloroquine may result in significant QT prolongation.
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TOPICS
Pandemic Perspectives: Q&A With K. Luan Phan, MD
In light of the COVID-19 pandemic, Psychiatry Advisor is making an effort to speak with providers from all professional backgrounds to gain insight into the field’s response to the current crisis.
Antiviral Merimepodib to Be Investigated in Phase 2 Trial for COVID-19
Following clearance of an Investigational New Drug Application by the Food and Drug Administration, ViralClear announced that a phase 2 study evaluating merimepodib oral solution for the treatment of coronavirus disease 2019 (COVID-19) will be initiated.
COVID-19 Fatality Rate High for Heart Transplant Recipients
Heart transplant (HT) recipients with COVID-19 infection have a case fatality rate of 25 percent.
High Incidence of Thromboembolic Events in Patients Who Died of COVID-19
Limited tablet cardiac ultrasound was found to represent an effective alternative to standard platform imaging for the screening of COVID-19-related cardiac conditions.
Transmission of SARS-CoV-2 From Patients to Healthcare Workers
Among 121 healthcare personnel exposed to a patient with unrecognized COVID-19, 43 became symptomatic and 3 tested positive for SARS-CoV-2.
Intensive Blood Pressure Control Tied to Lower Atrial Fibrillation Risk
Lowering systolic BP to <120 mm Hg lowers risk by 26 percent
ACE2 Plasma Concentrations Higher in Men vs Women With Heart Failure
Among patients with heart failure, men have higher plasma concentrations of angiotensin-converting enzyme 2.
Apremilast Improves Psoriatic Disease and Cardiometabolic Markers
A novel study assesses the safety and efficacy of apremilast in patients with psoriasis and evaluates the treatment as a metabolic modulator.
Factors Predicting Noninitiation of Anticoagulation Therapy After Venous Thromboembolism
Nearly 1 in 4 patients with incident venous thromboembolism were found not to initiate prescribed anticoagulation therapy in the month following hospital discharge.
CDC: Prevalence of Hypertension Higher in Rural Versus Urban Areas
The prevalence of hypertension varies across states and is higher in rural versus urban areas.
Pediatric ADHF Characterized by Comorbidities, High Mortality Rates
Acute decompensated heart failure in children is characterized by high burdens of comorbidities, mortality, and frequent readmission, especially among patients with underlying congenital heart disease.
Hypertension and Atrial Fibrillation Significantly Associated With Cerebrovascular Accidents in Systemic Sclerosis
Researchers evaluated the association between systemic sclerosis (SSc) and ischemic stroke, and determined risk factors for cerebrovascular accidents in SSc.
Nicardipine HCl Injection Now Available From American Regent
An AP-rated and therapeutically equivalent generic of Cardene IV (Chiesi) has been made available by American Regent.
Baseline NT-proBNP Found to Predict HF Events Without Modifying Sacubitril/Valsartan Effect in HFpEF
Baseline NT-proBNP levels were found to predict hospitalizations for heart failure (HF) and cardiovascular death in patients with HF with preserved ejection fraction.
Greater 5-Year Survival With Heart Transplant With or Without Bridge to Transplant LVAD vs LVAD Destination Therapy
Heart transplant with or without bridge to transplant LVAD therapy was found to be associated with greater 5-year survival compared with LVAD destination therapy in patients with end-stage heart failure.
Omecamtiv Mecarbil Gets Fast Track Status for Heart Failure
The FDA has granted Fast Track designation to omecamtiv mecarbil (Amgen) for the potential treatment of chronic heart failure with reduced ejection fraction (HFrEF).
COVID-19 mRNA Vaccine Candidates Advancing Through the Pipeline
A phase 2 study of Moderna’s vaccine candidate for COVID-19, mRNA-1273, is expected to start shortly following the Food and Drug Administration’s review of the Company’s Investigational New Drug (IND) application.
Teen Obesity, T2DM, Hypertension May Lead to Early Vascular Aging
The presence of obesity, type 2 diabetes, and elevated systolic blood pressure (SBP) in adolescence accelerates the progression of risk factors that play a role in the development of early vascular aging.
Oral Anticoagulation Found to Increase Bleeding Risk in Patients With HFrEF and Sinus Rhythm
Oral anticoagulation with or without antiplatelet medication was found to increase the risk for bleeding, with minimal protective effect against ischemic stroke in patients with heart failure with reduced ejection fraction and sinus rhythm.
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