The following article is a part of conference coverage from the American College of Cardiology’s 71st Annual Scientific Session & Expo being held in Washington, DC, from April 2 to 4, 2022. The team at Cardiology Advisor will be reporting on the latest news and research conducted by clinicians and scientists in the field. Check back for more from the ACC 2022 .
Blood type O candidates have a lower incidence of heart transplant and a higher incidence of delisting compared with non-type O candidates while on waitlist, according to research presented at the American College of Cardiology 71st Annual Scientific Session & Expo, from April 2nd through 4th, in Washington, DC.
Investigators aimed to assess the effect of a new allocation system on type O patient waitlist time and delisting. They searched the United Network for Organ Sharing database for all adults listed for first-time single-organ heart transplant from January 1, 2000, to December 31, 2020. Candidates who were listed from April 21, 2018, through October 18, 2018, were excluded to prevent inclusion of candidates who were listed in the new and previous allocation systems.
The study authors compared removal from the waitlist owing to heart transplant and delisting between type O and non-type O candidates with use of competing risks regression analysis.
The analysis showed that type O candidates have a lower incidence of heart transplant and an increased incidence of delisting compared with non-type O candidates while on waitlist.
The cumulative incidence of heart transplant in type O candidates was significantly lower compared with that of non-type O candidates in both the previous and new allocation systems (P <.01). The cumulative incidence of delisting was significantly increased in type O candidates (P ≤.01).
“Our study brings to light the limitations of our current allocation system in facilitating the heart transplant of blood type O candidates equitably prior to delisting,” the study authors wrote. “Further organ donation logistics simulation studies are needed to balance the discrepancy in allocation between type O and non-type O heart transplant.”
Kawabori M. The comparison of waitlist time and delisting in blood type O heart transplant candidates in the old and new donor allocation. Presented at: American College of Cardiology 71st Annual Scientific Session & Expo; April 2-4, 2022; Washington, DC.
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