Heart Failure

Dapagliflozin Lowers Heart Failure Hospitalization Rates in High-Risk Patients With Diabetes

Dapagliflozin Lowers Heart Failure Hospitalization Rates in High-Risk Patients With Diabetes

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Dapagliflozin was not associated with either a higher or lower rate of MACE compared with placebo in patients with type 2 diabetes who had or were at risk for atherosclerotic cardiovascular disease.

Sacubitril-Valsartan Superior to Enalapril for Reducing NT-proBNP in HFrEF

Sacubitril-Valsartan Superior to Enalapril for Reducing NT-proBNP in HFrEF

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A sacubitril-valsartan therapy regimen was associated with greater reductions in NT-proBNP concentrations in patients with HFrEF compared with enalapril.

Use of Both Aspirin and NSAIDs Associated With Incident Heart Failure Risk

Use of Both Aspirin and NSAIDs Associated With Incident Heart Failure Risk

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The use of both NSAID and aspirin was positively associated with incident HF in adults with no prior history of CVD.

Inhaled Nitrite Does Not Improve Exercise Capacity in HFpEF

Inhaled Nitrite Does Not Improve Exercise Capacity in HFpEF

Administration of inhaled nitrite is not associated with improvement in exercise capacity compared with placebo among patients with heart failure with preserved ejection fraction.

IABP Devices Being Evaluated By the FDA Due to Battery Complications

IABP Devices Being Evaluated By the FDA Due to Battery Complications

There have been over 75 medical device reports of the cardiac assist Maquet/Datascope IABP devices shutting down while running on battery.

Age, Racial Disparities Seen in Hospitalization for Heart Failure

Age, Racial Disparities Seen in Hospitalization for Heart Failure

For emergency department patients with heart failure, data reveal age and racial disparities in hospitalization rates.

Cardiac Stem Cell Trial Halted by NHLBI Due to Concerns About Fabricated Data

Cardiac Stem Cell Trial Halted by NHLBI Due to Concerns About Fabricated Data

A clinical trial assessing the use of stem cells to treat patients with heart failure has been paused by the US NHLBI because it is based partly on what may be falsified or fabricated data.

Data Support Efficacy of Heart Failure Hospital Readmissions Reduction Program

Data Support Efficacy of Heart Failure Hospital Readmissions Reduction Program

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The US Hospital Readmissions Reduction Program (HRRP) has successfully reduced readmission rates for certain conditions.

Risk for Congestive Heart Failure During Pregnancy in Cancer Survivors

Risk for Congestive Heart Failure During Pregnancy in Cancer Survivors

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Investigators sought to determine the incidence of cardiac decompensation during pregnancy in cancer survivors.

Some Antirheumatic Medications May Be Associated With Increased Heart Failure Risk in RA

Some Antirheumatic Medications May Be Associated With Increased Heart Failure Risk in RA

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A diagnosis of cardiovascular disease or presence of related biomarkers, as well as the use of antirheumatic drugs may be associated with a higher risk for heart failure in patients with rheumatoid arthritis.

Heart Failure: Transcatheter MV Repair May Decrease All-Cause Mortality vs Medical Therapy Alone

Heart Failure: Transcatheter MV Repair May Decrease All-Cause Mortality vs Medical Therapy Alone

Transcatheter mitral-valve repair results in a lower rate of hospitalization and lower all-cause mortality than medical therapy alone among patients with heart failure and moderate-to-severe secondary mitral regurgitation who remain symptomatic despite the use of guideline-directed medical therapy.

Takotsubo Syndrome Associated With Substantial Morbidity, Mortality

Takotsubo Syndrome Associated With Substantial Morbidity, Mortality

Patients with Takotsubo syndrome have lower mortality during the index admission than AMI patients but are frequently readmitted within 30 days.

Cardiac Outcomes in Pregnant Women Treated With Chemotherapy

Cardiac Outcomes in Pregnant Women Treated With Chemotherapy

The incidence of congestive heart failure during pregnancy is 31% among women with a history of cardiotoxicity associated with cancer treatment.

3D Echocardiography May Affect Decision to Implant an ICD in Subset of Patients

3D Echocardiography May Affect Decision to Implant an ICD in Subset of Patients

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LVEF values measured with 3DE were stronger predictors of major arrhythmic events than the same values calculated with 2DE.

Treatment for Transthyretin Amyloidosis Granted Orphan Drug Designation

Treatment for Transthyretin Amyloidosis Granted Orphan Drug Designation

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The Company expects to start Phase 3 studies for ATTR cardiomyopathy and polyneuropathy in the first half of 2019.

African Americans Less Likely to Receive Guideline‐Based NSTEMI Therapies

African Americans Less Likely to Receive Guideline‐Based NSTEMI Therapies

Black patients have a lower likelihood of receiving guideline-based therapies for non-ST-segment-elevation myocardial infarction.

Periprocedural ICD Complication Rates Among Older Adults Hospitalized With Heart Failure

Periprocedural ICD Complication Rates Among Older Adults Hospitalized With Heart Failure

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Patients currently or recently hospitalized for heart failure undergoing initial ICD placement experienced a higher rate of composite periprocedural complications compared with those without a recent heart failure hospitalization.

Research Gaps Linked to Limited Enrollment of Women in Heart Failure Clinical Trials

Research Gaps Linked to Limited Enrollment of Women in Heart Failure Clinical Trials

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Older patients, women, and racial and ethnic minorities are underrepresented in the majority of heart failure (HF) clinical trials.

Mortality Rate From Heart Failure Higher in Women Than Men

Mortality Rate From Heart Failure Higher in Women Than Men

Despite decreases in overall heart failure incidence and mortality in ambulatory patients from 2009 to 2014, mortality rates remain higher in women than in men.

Supraglottic airway resuscitation likely more or just as effective as endotracheal intubation for out-of-hospital cardiac arrest

In an American, randomized controlled trial, supraglottic airway (SGA) resuscitation was associated with marginally better neurological outcomes and 72-hour survival compared to endotracheal intubation (ETI) for patients with out-of-hospital cardiac arrests (OHCA).

LVAD in Heart Failure Linked to Improved Glycemic Control

LVAD in Heart Failure Linked to Improved Glycemic Control

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HbA1c levels following left ventricular assist device implantation were statistically significantly lower than before surgery.

FDA Fast Track Designation Granted to Praliciguat for HFpEF

FDA Fast Track Designation Granted to Praliciguat for HFpEF

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The Company is currently enrolling patients in a randomized, double-blind, placebo-controlled Phase 2 trial; they expect to enroll 175 in total.

Outcomes With Rivaroxaban in Chronic Heart Failure With Underlying CAD

Outcomes With Rivaroxaban in Chronic Heart Failure With Underlying CAD

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Rivaroxaban was not superior to placebo for reducing the rate of death, MI, or stroke in patients with chronic heart failure.

Tafamidis Reduces Mortality, Hospitalizations in Transthyretin Amyloid Cardiomyopathy

Tafamidis Reduces Mortality, Hospitalizations in Transthyretin Amyloid Cardiomyopathy

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Tafamidis was associated with reduced all-cause mortality and cardiovascular-related complications in patients with transthyretin amyloid cardiomyopathy.

Reducing HF Hospitalization Risk: Antidiabetic Drug Classes Compared

Reducing HF Hospitalization Risk: Antidiabetic Drug Classes Compared

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The authors searched for randomized placebo-controlled trials (December 1, 2008 to November 24, 2017) involving 3 pharmacologic classes of antidiabetic medications to compare the effects of these agents on the risk of hospitalization for HF in T2DM patients.

Evaluating Excess Risk for Heart Failure Hospitalization in Type 2 Diabetes

Evaluating Excess Risk for Heart Failure Hospitalization in Type 2 Diabetes

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Investigators examined the excess risk for heart failure in patients with type 2 diabetes and compared the risk with that in the general population without diabetes.

Labeling Mix-Up Prompts Recall of HCTZ Bottles That May Contain Another Diuretic

Labeling Mix-Up Prompts Recall of HCTZ Bottles That May Contain Another Diuretic

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To date, there have been no reports of any adverse events related to this recall.

Emphysema Associated With Worse Outcomes in Heart Failure

Emphysema Associated With Worse Outcomes in Heart Failure

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After 2.1 years of follow-up, 49% of patients who had emphysema on chest CT were readmitted for heart failure and 24% had died.

Entresto Initiation Soon After Acute HF Episode Safe in HFrEF Patients

Entresto Initiation Soon After Acute HF Episode Safe in HFrEF Patients

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The Phase 4, randomized, open-label, parallel-group TRANSITION study (N=1002) evaluated the safety and tolerability of Entresto in HFrEF patients after they were stabilized following an acute heart failure episode when treatment was initiated either pre-discharge or post-discharge.

New Clinical Trial Targets Gut Microbiota in Heart Failure

New Clinical Trial Targets Gut Microbiota in Heart Failure

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GutHeart, a new ongoing clinical trial, will investigate the potential benefits of treating gut bacteria in heart failure.

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