Heart Failure

FDA to Review Tafamidis for Treatment of Transthyretin Amyloid Cardiomyopathy

FDA to Review Tafamidis for Treatment of Transthyretin Amyloid Cardiomyopathy

By

Tafamidis is an oral small molecule candidate that selectively binds at specific sites on the transthyretin tetramer to prevent destabilization of the transthyretin transport protein and formation of amyloid that causes ATTR-CM.

Catheter Ablation Superior to Drug Therapy for Atrial Fibrillation in Heart Failure

Catheter Ablation Superior to Drug Therapy for Atrial Fibrillation in Heart Failure

By

Catheter ablation is superior to drug therapy in improving all-cause mortality, LVEF, 6-minute walk test distance, VO2max, and quality of life in patients with heart failure.

Influenza Infection Linked to Increased In-Hospital Mortality in Heart Failure

Influenza Infection Linked to Increased In-Hospital Mortality in Heart Failure

For patients with heart failure, influenza infection is associated with increased in-hospital morbidity and mortality.

Limited Alcohol Consumption Not Harmful for Seniors With Heart Failure

Limited Alcohol Consumption Not Harmful for Seniors With Heart Failure

For older adults with heart failure, limited alcohol consumption after diagnosis is associated with survival benefit versus long-term abstinence.

Program Reduces Mortality Among Medicare Beneficiaries Hospitalized for Heart Failure

Program Reduces Mortality Among Medicare Beneficiaries Hospitalized for Heart Failure

Announcement and implementation of the HRRP were associated with increased 30-day postdischarge mortality following hospitalization for heart failure and pneumonia.

Patient With Heart Failure Coughs Up Bronchial Tree-Shaped Blood Clot

Patient With Heart Failure Coughs Up Bronchial Tree-Shaped Blood Clot

By

A recently published case report describes the case of a 36-year-old male chronic heart failure patient who, "spontaneously expectorated an intact cast of the right bronchial tree," following an extreme bout of coughing.

Occupational Exposure to Metals, Pesticides Tied to CVD in Hispanics

Occupational Exposure to Metals, Pesticides Tied to CVD in Hispanics

Occupational exposures to pesticides and metals are associated with an increased prevalence of CVD among Hispanics/Latinos.

Follow-Up Within 7 Days of Hospital Discharge for Heart Failure Is Beneficial

Follow-Up Within 7 Days of Hospital Discharge for Heart Failure Is Beneficial

For patients with heart failure, follow-up care within seven days of discharge from the emergency department is associated with lower rates of long-term mortality and subsequent admissions.

Risk of Hospitalization for Heart Failure Greater With Diabetes Comorbidity

Risk of Hospitalization for Heart Failure Greater With Diabetes Comorbidity

Despite declining incidence, heart failure hospitalization is increased among individuals with diabetes.

Pregnancy Loss Associated With Increased CHD and Heart Failure Risk

Pregnancy Loss Associated With Increased CHD and Heart Failure Risk

Both pregnancy losses and a history of at least five live births are associated with an increased risk for cardiovascular disease.

Annual Flu Shots Shown to Reduce CV Death Risk in Heart Failure

Annual Flu Shots Shown to Reduce CV Death Risk in Heart Failure

By

A study published in Circulation has found a reduced risk of cardiovascular (CV) death in heart failure patients when they are given routine influenza vaccinations.

Clinicians May Not Be Addressing Functional Impairment When Prescribing HF Medication

Clinicians May Not Be Addressing Functional Impairment When Prescribing HF Medication

For individuals with heart failure, those with impairment in activities of daily living take as many medications as those without ADL impairment.

Radiofrequency Renal Denervation Inhibits RAS in Heart Failure

Radiofrequency Renal Denervation Inhibits RAS in Heart Failure

By

Compared with the sham control, there were noticeable reductions in renal norepinephrine levels and circulating angiotensin I and II in swine that underwent radiofrequency renal denervation.

Predictors of Transcatheter Mitral Valve Repair Quality of Life Outcomes

Predictors of Transcatheter Mitral Valve Repair Quality of Life Outcomes

By

Having atrial fibrillation, using home oxygen, having severe lung disease, or having a permanent pacemaker were predictive of lower health status after transcatheter mitral valve repair.

Androgen Deprivation Therapy May Increase Risk for Heart Failure in Prostate Cancer

Androgen Deprivation Therapy May Increase Risk for Heart Failure in Prostate Cancer

For patients with prostate cancer, androgen deprivation therapy is associated with an increased risk for heart failure.

Quality-of-Life Outcomes With Natriuretic Peptide-Guided Therapy for Heart Failure

Quality-of-Life Outcomes With Natriuretic Peptide-Guided Therapy for Heart Failure

By

An N-terminal pro-B-type natriuretic peptide-guided treatment strategy is more costly and non-superior to usual care in heart failure.

Dapagliflozin Lowers Heart Failure Hospitalization Rates in High-Risk Patients With Diabetes

Dapagliflozin Lowers Heart Failure Hospitalization Rates in High-Risk Patients With Diabetes

By

Dapagliflozin was not associated with either a higher or lower rate of MACE compared with placebo in patients with type 2 diabetes who had or were at risk for atherosclerotic cardiovascular disease.

Sacubitril-Valsartan Superior to Enalapril for Reducing NT-proBNP in HFrEF

Sacubitril-Valsartan Superior to Enalapril for Reducing NT-proBNP in HFrEF

By

A sacubitril-valsartan therapy regimen was associated with greater reductions in NT-proBNP concentrations in patients with HFrEF compared with enalapril.

Use of Both Aspirin and NSAIDs Associated With Incident Heart Failure Risk

Use of Both Aspirin and NSAIDs Associated With Incident Heart Failure Risk

By

The use of both NSAID and aspirin was positively associated with incident HF in adults with no prior history of CVD.

Inhaled Nitrite Does Not Improve Exercise Capacity in HFpEF

Inhaled Nitrite Does Not Improve Exercise Capacity in HFpEF

Administration of inhaled nitrite is not associated with improvement in exercise capacity compared with placebo among patients with heart failure with preserved ejection fraction.

IABP Devices Being Evaluated By the FDA Due to Battery Complications

IABP Devices Being Evaluated By the FDA Due to Battery Complications

There have been over 75 medical device reports of the cardiac assist Maquet/Datascope IABP devices shutting down while running on battery.

Age, Racial Disparities Seen in Hospitalization for Heart Failure

Age, Racial Disparities Seen in Hospitalization for Heart Failure

For emergency department patients with heart failure, data reveal age and racial disparities in hospitalization rates.

Cardiac Stem Cell Trial Halted by NHLBI Due to Concerns About Fabricated Data

Cardiac Stem Cell Trial Halted by NHLBI Due to Concerns About Fabricated Data

A clinical trial assessing the use of stem cells to treat patients with heart failure has been paused by the US NHLBI because it is based partly on what may be falsified or fabricated data.

Data Support Efficacy of Heart Failure Hospital Readmissions Reduction Program

Data Support Efficacy of Heart Failure Hospital Readmissions Reduction Program

By

The US Hospital Readmissions Reduction Program (HRRP) has successfully reduced readmission rates for certain conditions.

Risk for Congestive Heart Failure During Pregnancy in Cancer Survivors

Risk for Congestive Heart Failure During Pregnancy in Cancer Survivors

By

Investigators sought to determine the incidence of cardiac decompensation during pregnancy in cancer survivors.

Some Antirheumatic Medications May Be Associated With Increased Heart Failure Risk in RA

Some Antirheumatic Medications May Be Associated With Increased Heart Failure Risk in RA

By

A diagnosis of cardiovascular disease or presence of related biomarkers, as well as the use of antirheumatic drugs may be associated with a higher risk for heart failure in patients with rheumatoid arthritis.

Heart Failure: Transcatheter MV Repair May Decrease All-Cause Mortality vs Medical Therapy Alone

Heart Failure: Transcatheter MV Repair May Decrease All-Cause Mortality vs Medical Therapy Alone

Transcatheter mitral-valve repair results in a lower rate of hospitalization and lower all-cause mortality than medical therapy alone among patients with heart failure and moderate-to-severe secondary mitral regurgitation who remain symptomatic despite the use of guideline-directed medical therapy.

Takotsubo Syndrome Associated With Substantial Morbidity, Mortality

Takotsubo Syndrome Associated With Substantial Morbidity, Mortality

Patients with Takotsubo syndrome have lower mortality during the index admission than AMI patients but are frequently readmitted within 30 days.

Cardiac Outcomes in Pregnant Women Treated With Chemotherapy

Cardiac Outcomes in Pregnant Women Treated With Chemotherapy

The incidence of congestive heart failure during pregnancy is 31% among women with a history of cardiotoxicity associated with cancer treatment.

3D Echocardiography May Affect Decision to Implant an ICD in Subset of Patients

3D Echocardiography May Affect Decision to Implant an ICD in Subset of Patients

By

LVEF values measured with 3DE were stronger predictors of major arrhythmic events than the same values calculated with 2DE.

Sign Up for Free e-Newsletters