HealthDay News — Primary care providers should make individual decisions whether to prescribe aspirin based on a benefit-to-risk ratio, not simply age, according to a review published online Dec. 24 in Family Medicine and Community Health.

Kyungmann Kim, Ph.D., from the University of Wisconsin-Madison, and colleagues conducted a systematic literature search to identify phase 3 randomized, double-blind placebo-controlled trials of aspirin in the primary prevention of cardiovascular disease (CVD) published in English between publication of the Antithrombotic Trialists (ATT) Collaboration meta-analysis (May 30, 2009) and July 31, 2021.

Based on the four identified trials added to the six from the ATT, the researchers found that aspirin produced a statistically significant 13 percent reduction in CVD, with similar benefits seen at older ages in each of the trials. With >10 percent absolute risk for CVD, benefits of aspirin generally outweighed risks for significant bleeding.


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“Our perspective is that individual clinical judgments by primary care providers about prescription of aspirin in primary prevention of CVD should be based on our evidence-based solution of weighing all the absolute benefits and risks rather than age,” the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Bayer.

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