Dyslipidemia

Statin Therapy Reduces Risk for Diabetic Retinopathy in Type 2 Diabetes

Statin Therapy Reduces Risk for Diabetic Retinopathy in Type 2 Diabetes

Reduced risk, slowed progression of retinopathy for Taiwanese patients with type 2 diabetes, dyslipidemia

Safety of PCSK9 Inhibitors After Heart Transplantation Examined

Safety of PCSK9 Inhibitors After Heart Transplantation Examined

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PCSK9 inhibitors are a potentially safe lipid-lowering therapy for heart transplant recipients with suboptimal LDL management on statins.

Evolocumab Autoinjectors, Pre-Filled Syringes Now Available at Reduced List Price

Evolocumab Autoinjectors, Pre-Filled Syringes Now Available at Reduced List Price

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Amgen announced that all Repatha (evolocumab) devices are now available at a 60% reduced list price. This includes the pre-filled syringe, the SureClick autoinjector, and the Pushtronex device, an on-body infusor with prefilled cartridge.

High-Intensity Statins Affect Coronary Plaque Composition After STEMI

High-Intensity Statins Affect Coronary Plaque Composition After STEMI

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Patients using a high-intensity statin after a STEMI experienced a significant increase in minimum fibrous cap thickness.

Further Reductions in Alirocumab Price Needed to Be Considered Cost-Effective

Further Reductions in Alirocumab Price Needed to Be Considered Cost-Effective

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For alirocumab to be considered cost-effective compared with generic ezetimibe, its annual price would have to be reduced to less than $90.

CVD Risk Factors in Heterozygous Familial Hypercholesterolemia

CVD Risk Factors in Heterozygous Familial Hypercholesterolemia

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Smoking, hypertension, and diabetes contributed to more than a quarter of excess CVD risk in individuals with heterozygous familiar hypercholesterolemia.

Hypobetalipoproteinemia Associated With Aggression and Schizophrenia

Hypobetalipoproteinemia Associated With Aggression and Schizophrenia

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Study results showed that the prevalence of hypobetalipoproteinemia was 4-fold higher in the psychiatric group compared with the general population.

Serum Cholesterol Efflux Capacity Inversely Associated With Mortality After MI

Serum Cholesterol Efflux Capacity Inversely Associated With Mortality After MI

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An integrative marker of the reverse cholesterol transport pathway was inversely associated with all-cause mortality in MI.

Familial Hypercholesterolemia: An Underdiagnosed Disease Gets a Second Look

Familial Hypercholesterolemia: An Underdiagnosed Disease Gets a Second Look

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Despite the frequency with which it occurs, familial hypercholesterolemia often goes undiagnosed, with only 10% of affected patients aware of this genetic disorder.

Ultrasonography and MRI May Improve Diagnosis of Achilles Tendon Xanthoma in FH

Ultrasonography and MRI May Improve Diagnosis of Achilles Tendon Xanthoma in FH

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Ultrasonography or MRI may improve diagnosis of ATX in familial hypercholesterolemia, identifying patients at risk for more severe coronary artery disease.

Robust LDL-C Reduction With Alirocumab in Patients Who Tolerate Only Lowest Statin Doses

Robust LDL-C Reduction With Alirocumab in Patients Who Tolerate Only Lowest Statin Doses

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Hypercholesterolemic patients who tolerate only lowest-dose statin or non-statin lipid lowering therapy can achieve LDL-C reduction with alirocumab.

Adherence and Intensity of Lipid-Lowering Therapy Influence CV Risk

Adherence and Intensity of Lipid-Lowering Therapy Influence CV Risk

Adherent patients receiving high-intensity statin and/or ezetimibe therapy have the lowest cardiovascular risk.

Should Guidelines Use Higher Risk Thresholds When Recommending Statins for Primary CVD Prevention?

Should Guidelines Use Higher Risk Thresholds When Recommending Statins for Primary CVD Prevention?

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Guidelines should incorporate using higher 10-year risk thresholds when recommending statins for the purpose of primary CVD prevention.

AHA Scientific Statement: Low Risk of Side Effects With Statins

AHA Scientific Statement: Low Risk of Side Effects With Statins

Statins are associated with a low risk for side effects, according to a scientific statement from the American Heart Association.

Long-Term Clinical Outcomes of Statin Therapy Post-PCI in Absence of Dyslipidemia

Long-Term Clinical Outcomes of Statin Therapy Post-PCI in Absence of Dyslipidemia

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A positive relationship was found between statin use and MACE-free survival after AMI regardless of the presence or absence of dyslipidemia.

Statin Use May Improve Bone Microstructure in Women With Osteoporosis

Statin Use May Improve Bone Microstructure in Women With Osteoporosis

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Statin use is associated with better cortical bone characteristics in older women with osteoporosis, but results are dependent upon the potency of the statins.

Coronary Artery Calcium Associated With ASCVD Events in Familial Hypercholesterolemia

Coronary Artery Calcium Associated With ASCVD Events in Familial Hypercholesterolemia

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CAC was found to be independently associated with ASCVD events in familiar hypercholesterolemia treated with standard lipid lowering therapy.

Elevated Triglyceride Levels Affect Glycemic Control in Type 2 Diabetes

Elevated Triglyceride Levels Affect Glycemic Control in Type 2 Diabetes

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Reducing triglyceride levels in patients with type 2 diabetes may help them attain more optimal glycemic control.

Linear Association Between Plasma Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression

Linear Association Between Plasma Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression

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Lipoprotein(a) levels should be measured in mild to moderate calcific aortic valve stenosis to improve patient risk stratification.

Hyperlipidemia Screening Rates Low Among Patients With Rheumatoid Arthritis

Hyperlipidemia Screening Rates Low Among Patients With Rheumatoid Arthritis

Primary lipid screening rates were suboptimal among patients with rheumatoid arthritis.

ACC Releases Consensus Decision Pathway for CVD Risk Reduction in T2D and ASCVD

ACC Releases Consensus Decision Pathway for CVD Risk Reduction in T2D and ASCVD

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The American College of Cardiology published an expert consensus statement regarding decision considerations for novel cardiovascular risk reduction therapies in patients with type 2 diabetes and atherosclerotic cardiovascular disease.

Statin Use Does Not Modify Flu Vaccine Effectiveness in Adults

Statin Use Does Not Modify Flu Vaccine Effectiveness in Adults

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Statin use did not modify the effect of vaccination on influenza in adults ≥45 years.

Onset of Musculoskeletal Adverse Events Varies Between Statins

Onset of Musculoskeletal Adverse Events Varies Between Statins

The onset of musculoskeletal adverse events during statin monotherapy is significantly faster with use of atorvastatin and rosuvastatin versus simvastatin.

Simvastatin Improves Platelet Activation Markers in Primary Hypercholesterolemia

Simvastatin Improves Platelet Activation Markers in Primary Hypercholesterolemia

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In patients with primary hypercholesterolemia, short-term treatment with simvastatin improved the lipid profile and exerted a beneficial effect on a wide range of proatherogenic and prothrombotic parameters.

Total CV Event Reduction More Effectively Assesses Alirocumab Efficacy After ACS

Total CV Event Reduction More Effectively Assesses Alirocumab Efficacy After ACS

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Total cardiovascular event reduction may represent a more comprehensive metric to assess alirocumab clinical efficacy after acute coronary syndrome.

Updated Guidelines Stress Healthy Lifestyle for Cholesterol Management

Updated Guidelines Stress Healthy Lifestyle for Cholesterol Management

A healthy lifestyle for lowering cholesterol should be emphasized for reducing cardiovascular risk across the life course, according to a guideline.

AHA/ACC Release Updated Guidelines for Cholesterol Management

AHA/ACC Release Updated Guidelines for Cholesterol Management

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Updated cholesterol guidelines offer more personalized cardiovascular disease risk assessment.

Omega-3 Fatty Acids Reduce MACE in Mild Hypertriglyceridemia

Omega-3 Fatty Acids Reduce MACE in Mild Hypertriglyceridemia

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In high-risk patients with mild hypertriglyceridemia, omega-3 fatty acids improved triglyceride levels and reduced major adverse cardiovascular events, according to a new meta-analysis.

Ezetimibe Plus Statin Therapy Yields Greater Cost-Savings vs Evolocumab

Ezetimibe Plus Statin Therapy Yields Greater Cost-Savings vs Evolocumab

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Compared with evolocumab, the addition of ezetimibe to statin therapy is a major cost-saving strategy for preventing cardiovascular (CV) death in patients with T2D and an established CV disease.

Statin-Induced Musculoskeletal AEs and Timing of Concurrent Therapy Examined

Statin-Induced Musculoskeletal AEs and Timing of Concurrent Therapy Examined

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The data showed MAEs onset was significantly faster with atorvastatin and rosuvastatin compared with simvastatin; a comparison with other statins could not be established due to the small number of cases identified.

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