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Breathing New Life Into COPD and Asthma Therapy With Statins

Breathing New Life Into COPD and Asthma Therapy With Statins

Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.

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Breathing New Life Into COPD and Asthma Therapy With Statins

Breathing New Life Into COPD and Asthma Therapy With Statins

Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.

PCSK9 Inhibitor Alirocumab Associated With 75% Reduction in Apheresis

PCSK9 Inhibitor Alirocumab Associated With 75% Reduction in Apheresis

Among patients with heterozygous familial hypercholesterolemia, alirocumab was associated with a 75% reduction in lipoprotein apheresis compared with placebo.

Statins Limit Vaccine Efficacy of Influenza Strain

Statins Limit Vaccine Efficacy of Influenza Strain

Statin use modified vaccine effectiveness and influenza risk for A(H3N2) infection but not for A(H1N1).

Higher Vitamin D Levels May Related to Higher Total Cholesterol, HDL-C

Higher Vitamin D Levels May Related to Higher Total Cholesterol, HDL-C

Vitamin D may influence cardiovascular disease risk via its effect on lipid levels.

Considering Cardiovascular Risks of Antidiabetic Drugs

Considering Cardiovascular Risks of Antidiabetic Drugs

A review of current antidiabetic drug treatments available and their individual cardiovascular risk profiles.

PCSK9 Inhibitors: Breakthrough in LDL-C Reduction, But Comes at a Cost

PCSK9 Inhibitors: Breakthrough in LDL-C Reduction, But Comes at a Cost

PCSK9 inhibitors may offer hope to patients with familial hypercholesterolemia who cannot tolerate or achieve goal LDL-C levels with statins.

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Many AKI Reports in FAERS Linked to Drugs Not Recognized as Nephrotoxic

Many AKI Reports in FAERS Linked to Drugs Not Recognized as Nephrotoxic

According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using this database.

Increased Arterial Stiffness Observed in Patients With Systemic Lupus Erythematosus

Increased Arterial Stiffness Observed in Patients With Systemic Lupus Erythematosus

Patients with systemic lupus erythematosus exhibit increased central arterial stiffness compared with a healthy control population.

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

LDL-C Reduction Examined With Different Evolocumab Dosing Regimens

For this study, researchers investigated the pharmacodynamics of evolocumab in two Phase 2 placebo-controlled studies (MENDEL and LAPLACE-TIMI 57) in order to determine which dosing regimens provided the most consistent LDL-C reduction.

Intensive LDL-C lowering reduces mortality in patients with higher baseline LDL-C

More intensive compared with less intensive LDL-C lowering therapy was associated with a greater risk reduction for total and cardiovascular mortality in trials of patients with higher baseline LDL-C levels.

FDA Committee in Favor of Waylivra for Rare Metabolic Lipid Disorder

FDA Committee in Favor of Waylivra for Rare Metabolic Lipid Disorder

Antisense technology refers to the use of synthetic nucleic acid sequences to interrupt specific protein production by targeting the corresponding messenger RNA that encodes that protein.

Higher LDL-C Levels Derive Most Benefit From More Intensive Therapy

Higher LDL-C Levels Derive Most Benefit From More Intensive Therapy

Patients with higher low-density lipoprotein cholesterol levels experienced the greatest reductions in all-cause and cardiovascular mortality from intensive therapy.

Breathing New Life Into COPD and Asthma Therapy With Statins

Breathing New Life Into COPD and Asthma Therapy With Statins

Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.

Outcomes-Based Pricing Does Not Cut Costs of PCSK9 Inhibitors

Outcomes-Based Pricing Does Not Cut Costs of PCSK9 Inhibitors

Incremental cost-effectiveness ratio for PCSK9 inhibitor improved marginally in 3 refund scenarios.

Only Half of Adults With Familial Hypercholesterolemia on Statins

Only Half of Adults With Familial Hypercholesterolemia on Statins

Only 30.3 percent of patients with definite or probable FH on statins take a high-intensity statin.

Metformin Use Linked to Reduced Risk for Statin-Associated Muscle Pain

Metformin Use Linked to Reduced Risk for Statin-Associated Muscle Pain

Statin-associated muscle pain can hinder medication adherence which could potentially lead to an increased risk of cardiovascular events.

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