Indications for TRIFERIC:
Iron replacement to maintain hemoglobin in adults with hemodialysis-dependent chronic kidney disease (HDD-CKD).
Limitations of Use:
Not for use in patients receiving peritoneal dialysis. Not studied in patients receiving home hemodialysis.
See full labeling. Must add soln (5mL or 50mL amp) or pwd (1 pkt) to bicarbonate concentrate (2.5 or 25gallons) for generation of hemodialysate. Final concentration (Triferic/in hemodialysate): 2micromolar (100mcg/L). Administer at each dialysis procedure.
Monitor for hypersensitivity reactions during and after hemodialysis until clinically stable. Have personnel and resuscitative equipment immediately available. Determine iron status on pre-dialysis blood samples. Pregnancy. Advise females of reproductive potential to use effective contraception during and for at least 2weeks after therapy completion. Nursing mothers.
Headache, peripheral edema, asthenia, AV fistula thrombosis, urinary tract infection, AV fistula site hemorrhage, pyrexia, fatigue, procedural hypotension, muscle spasms, pain in extremity, back pain, dyspnea.
Generic Drug Availability:
Ampules (5mL)—5, 40; (50mL)—4, 24; Single-dose ampules (4.5mL)—10, 40; Packets— 1, 100