Indications for: KLOXXADO
Reversal of known or suspected opioid overdose, including respiratory and/or CNS depression.
Limitations of Use:
Not a substitute for emergency medical care.
Adults and Children:
Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3mins in alternate nostrils if unresponsive or relapses into respiratory depression. Seek immediate emergency medical assistance after the first dose.
Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.
Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.
Abdominal pain, asthenia, dizziness, headache, nasal discomfort, presyncope; opioid withdrawal.
Generic Drug Availability:
Single-dose nasal spray—2