Indications for ACZONE:
Wash skin and pat dry. Apply pea-sized amount to affected area in a thin layer twice daily in the AM & PM. Rub in gently and completely. Wash hands after use. Reevaluate if no improvement after 12 weeks.
<12yrs: not recommended.
Avoid in congenital or idiopathic methemoglobinemia. G6PD deficiency: may have increased risk of methemoglobinemia or hemolytic anemia; discontinue if occurs. Pregnancy. Nursing mothers.
Increased risk of hemolysis in G6PD-deficient patients with concomitant trimethoprim/sulfamethoxazole, other folic acid antagonists (eg, pyrimethamine), anticonvulsants, rifampin, St. John's wort. Increased risk of methemoglobinemia with concomitant sulfonamides, acetaminophen, chloroquine, nitrates, nitrites, nitrofurantoin, phenobarbital, phenytoin, primaquine, quinine, and others. Skin/hair discoloration with topical benzoyl peroxide.
Application site reactions (oiliness, peeling, dryness, erythema, pruritus).
Generic Drug Availability:
Gel 5% (tubes)—30g, 60g, 90g; Gel 7.5% (pumps)—30g, 60g, 90g