Indications for: Acyclovir
Genital herpes. Herpes zoster. Varicella.
May give with food. Genital herpes: Initially 200mg every 4hrs (5 times daily) for 10 days. Chronic: 400mg 2 times daily or 200mg 3–5 times daily for up to 12 months, then reevaluate. Intermittent: (at 1st sign of recurrence) 200mg every 4hrs (5 times daily) for 5 days. Herpes zoster: 800mg every 4hrs (5 times daily) for 7–10 days. Varicella (start at earliest sign/symptom): 800mg 4 times daily for 5 days. Renal impairment: reduce dose (see full labeling); give another dose after hemodialysis.
<2yrs: not recommended. ≥2yrs: Varicella (start at earliest sign/symptom): 20mg/kg 4 times daily for 5 days; max 800mg/dose. >40kg: as adult. Others: see full labeling.
Renal impairment: see full labeling. Maintain adequate hydration. Pregnancy (Cat.B). Nursing mothers.
Avoid nephrotoxic drugs. Potentiated by probenecid.
Nausea, vomiting, headache, CNS disturbances (esp. elderly), diarrhea, vertigo, myalgia, rash, malaise, viral resistance, renal failure, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in immunocompromised patients.
Formerly known under the brand name Zovirax.
Caps, tabs—contact supplier; Susp—473mL