General (including evidence of efficacy) What classes of antiplatelet drugs should be prescribed after an acute coronary syndrome? 1. Aspirin Mechanism of action: Irreversibly inhibits the platelet COX-1 enzyme leading to reduced thromboxane A2 (TXA2) production. In turn, this inhibits platelet activation and aggregation via TXA2-dependent pathways and blocks TXA2-dependent vasoconstriction. Efficacy of aspirin: In…
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